[HTML][HTML] Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia–reperfusion injury

J Wang, H Zhou - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Thyroid hormones interaction with immune response, inflammation and non-thyroidal illness syndrome

R De Luca, PJ Davis, HY Lin, F Gionfra… - Frontiers in cell and …, 2021 - frontiersin.org
The interdependence between thyroid hormones (THs), namely, thyroxine and
triiodothyronine, and immune system is nowadays well-recognized, although not yet fully …

PINK1: The guard of mitochondria

N Wang, P Zhu, R Huang, C Wang, L Sun, B Lan, Y He… - Life sciences, 2020 - Elsevier
PTEN-induced putative kinase 1 (PINK1) performs many important functions in cells and has
been highlighted for its role in early-onset Parkinson's disease. In recent years, an …

Hypothyroidism and risk of cardiovascular disease

ZM Gluvic, SS Zafirovic, MM Obradovic… - Current …, 2022 - ingentaconnect.com
Thyroid hormones (TH) have a significant impact on cellular oxidative metabolism. Besides
that, they maintain vascular homeostasis by positive effects on endothelial and vascular …

Levothyroxine for the treatment of subclinical hypothyroidism and cardiovascular disease

LY Sue, AM Leung - Frontiers in endocrinology, 2020 - frontiersin.org
Subclinical hypothyroidism is a biochemical condition defined by elevated serum thyroid-
stimulating hormone levels in the setting of normal levels of the peripheral thyroid hormones …

[HTML][HTML] Therapeutic effects of the combination of moderate-intensity endurance training and MitoQ supplementation in rats with isoproterenol-induced myocardial …

F Rostamzadeh, H Najafipour, S Aminizadeh… - Biomedicine & …, 2024 - Elsevier
Introduction Mitochondrial dysfunction causes myocardial disease. This study investigated
the effects of MitoQ alone and in combination with moderate-intensity endurance training …

Mitochondrial calcium overload plays a causal role in oxidative stress in the failing heart

H Dridi, G Santulli, L Bahlouli, MC Miotto, G Weninger… - Biomolecules, 2023 - mdpi.com
Heart failure is a serious global health challenge, affecting more than 6.2 million people in
the United States and is projected to reach over 8 million by 2030. Independent of etiology …

Mitochondria-targeted drug delivery in cardiovascular disease: a long road to nano-cardio medicine

F Forini, P Canale, G Nicolini, G Iervasi - Pharmaceutics, 2020 - mdpi.com
Cardiovascular disease (CVD) represents a major threat for human health. The available
preventive and treatment interventions are insufficient to revert the underlying pathological …

Local modulation of thyroid hormone signaling in the retina affects the development of diabetic retinopathy

F Forini, G Nicolini, R Amato, S Balzan, A Saba… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Thyroid hormone (TH) dyshomeostasis is associated with poor prognosis in acute and
prolonged illness, but its role in diabetic retinopathy (DR) has never been investigated …

Selenium involvement in mitochondrial function in thyroid disorders

ML Gheorghiu, C Badiu - Hormones, 2020 - Springer
Selenium (Se), an important oligoelement, is a component of the antioxidant system. Over
the last decade, it has been ever more frequently discussed in the context of thyroid …