Twenty-five years of clinical applications using adaptive optics ophthalmoscopy

JIW Morgan, TYP Chui, K Grieve - Biomedical Optics Express, 2022 - opg.optica.org
Twenty-five years ago, adaptive optics (AO) was combined with fundus photography,
thereby initiating a new era in the field of ophthalmic imaging. Since that time, clinical …

Redefining our vision: an updated guide to the ocular immune system

M Wu, EL Fletcher, HR Chinnery, LE Downie… - Nature Reviews …, 2024 - nature.com
Balanced immune responses in the eyes are crucial to preserve vision. The ocular immune
system has long been considered distinct, owing to the so-called 'immune privilege'of its …

Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease

A Rajesh, S Droho, JA Lavine - Journal of neuroinflammation, 2022 - Springer
Background Diabetic retinopathy and retinal vein occlusion are vision threatening retinal
vascular diseases. Current first-line therapy targets the vascular component, but many …

Ultrahigh-speed multimodal adaptive optics system for microscopic structural and functional imaging of the human retina

Z Liu, F Zhang, K Zucca, A Agrawal… - Biomedical optics …, 2022 - opg.optica.org
We describe the design and performance of a multimodal and multifunctional adaptive
optics (AO) system that combines scanning laser ophthalmoscopy (SLO) and optical …

Macrophage-like cells are increased in patients with vision-threatening diabetic retinopathy and correlate with macular edema

NT Zhang, PL Nesper, JX Ong, JM Wang, AA Fawzi… - Diagnostics, 2022 - mdpi.com
Macrophage-like cells (MLCs) are potential inflammatory biomarkers. We previously showed
that MLCs are increased in proliferative diabetic retinopathy (PDR) eyes. Vision-threatening …

Macrophage-like cells are still detectable on the retinal surface after posterior vitreous detachment

JM Wang, JX Ong, PL Nesper, AA Fawzi, JA Lavine - Scientific reports, 2022 - nature.com
The identity of vitreoretinal interface macrophage-like cells (MLCs) remains unknown and
potential candidates include retinal microglia, perivascular macrophages, monocyte-derived …

Proliferative diabetic retinopathy and diabetic macular edema are two factors that increase macrophage-like cell density characterized by en face optical coherence …

W Wang, G Sun, A Xu, C Chen - BMC ophthalmology, 2023 - Springer
Abstract Background Macrophage-like cells (MLCs) located at the ILM were observed in live
human retinas using adaptive optics optical coherence tomography (OCT) as well as …

Macrophage-like cells characterized by en face optical coherence tomography was associated with fluorescein vascular leakage in behçet's uveitis

Y Zeng, X Zhang, L Mi, Y Ji, X Zhuang… - Ocular immunology …, 2023 - Taylor & Francis
Purpose To investigate the features of macrophage-like cell (MLC) characterized by en face
optical coherence tomography (OCT) in Behçet's uveitis (BU). Methods The extent of …

Hyalocytes in proliferative vitreo-retinal diseases

CH Jones, W Gui, RG Schumann… - Expert review of …, 2022 - Taylor & Francis
Introduction Hyalocytes are sentinel macrophages residing within the posterior vitreous
cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and …

Minimum intensity projection of embossed quadrant-detection images for improved photoreceptor mosaic visualisation

A Kalitzeos, M Michaelides, A Dubra - Frontiers in Ophthalmology, 2024 - frontiersin.org
Non-confocal split-detection imaging reveals the cone photoreceptor inner segment mosaic
in a plethora of retinal conditions, with the potential of providing insight to ageing, disease …