The unique properties of fluorine-containing organic compounds make fluorine substitution
attractive for the development of pharmaceuticals and various specialty materials, which …

Covering: 2012. Previous review: Nat. Prod. Rep., 2013, 30, 237–323. This review covers
the literature published in 2012 for marine natural products, with 1035 citations (673 for the …

Attachment of isoprene units to various acceptors by prenylation plays an important role in
primary and secondary metabolism of living organisms. Protein prenylation belongs to …

Herein, we report carbene-mediated benzannulation of vinyl sulfoxonium ylides with
electron-deficient alkynes and alkenes to synthesize oxygenated arenes. This protocol …

Epidermal growth factor receptor (EGFR) has been recognized as one of the attractive
targets for anticancer drug development. Herein, a set of anilino-1, 4-naphthoquinone …

Despite recognition of the looming antibiotic crisis by healthcare professionals, the number
of new antibiotics reaching the clinic continues to decline sharply. This study aimed to …

The search for new bioactive compounds with innovative modes of action and chemistry are
desperately needed to tackle the increased emergence of drug-resistant microbes. With this …

The review is devoted to the chemical diversity of steroids produced by soft corals and their
determined and potential activities. There are about 200 steroids that belong to different …

Abstract A novel series of 1, 4-naphthoquinones (33–44) tethered by open and closed chain
sulfonamide moieties were designed, synthesized and evaluated for their cytotoxic and …

A highly enantioselective formal coupling of β-ketoesters with quinones was accomplished
by a chiral bifunctional N-heterocyclic olefin organocatalyst. With as low as 1 mol% catalyst …