Saffron, a spice derived from the flower of Crocus sativus, is rich in carotenoids. Two main
natural carotenoids of saffron, crocin and crocetin, are responsible for its color. Preclinical …

The i-motif structure is formed in cytosine-rich sequences, its building block being the
cytosine· cytosine+ base pair. This structure is particularly stable at pH values below …

Objectives Crocin is derived from dried stigmas of Crocus sativus L.(saffron). It has long
been used to prevent and treat various diseases. Although crocin is suggested as one of the …

We previously showed the anticancer property of crocin, a carotenoid isolated and purified
from saffron against chemical-induced gastric and breast cancer in rats. In this study, the …

Many bioactive agents have been extracted from plants or belong to functional foods and
have been considered in the treatment of serious and multifactorial diseases, such as …

Abstract Background In 1957, Francis Crick drew a linear diagram on a blackboard. This
diagram is often called the “central dogma.” Subsequently, the relationships between …

This study investigated the therapeutic effect of crocetin, a carotenoid derived from saffron,
on gastric adenocarcinoma (AGS) cells and 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) …

The immune system when acts against selfmolecules results in an imbalance in
immunologic tolerance leading to the development of several autoimmune diseases (ADs) …

Functionalized nanoparticles are specifically designed to deliver drugs at tumor cells and
can potentially enhance anticancer activity of drugs such as crocin. In the present study, we …

We previously showed the anticancer effect of crocin, a saffron carotenoid, in both breast
and gastric cancers in animal models, but its mechanism of action is not clearly known, yet …