Remarkable progress has been made in islet transplantation over a span of 40 years. Once
just an experimental curiosity in mice, this therapy has moved forward, and can now provide …

Abstract The phosphatidylinositiol 3-kinase (PI3K), AKT, mammalian target of rapamycin
(mTOR) signaling pathway (PI3K/AKT/mTOR) is frequently dysregulated in disorders of cell …

Viruses are among the most common causes of opportunistic infection after transplantation.
The risk for viral infection is a function of the specific virus encountered, the intensity of …

A complex interplay of intracellular signaling networks orchestrates normal cell growth and
survival, including translation, transcription, proliferation, and cell cycle progression …

Despite advancements in cancer management, tumor relapse and metastasis are
associated with poor outcomes in many cancers. Over the past decade, oncogene-driven …

Results Using this workflow, we attempted to recontact a diverse pilot cohort of 104
nephrology research participants with actionable genetic findings, encompassing 34 …

Background. The association of immunosuppressive regimens (ISRs) with posttransplant
lymphoproliferative disorder (PTLD) may be related with the Epstein-Barr virus (EBV) …

The routine therapies for relapsing-remitting multiple sclerosis (RRMS) are common disease-
modifying medications, yet are not effective in all patients. The aim of the present clinical trial …

The treatment of advanced renal cell carcinoma (RCC) remains a major therapeutic
challenge for clinicians. Despite advances in the understanding of the immunobiology of …

Background Skin cancer is the most common malignancy to arise after organ transplantation
in Caucasians, but limited data are available on its incidence in Asian transplant recipients …