Leishmaniasis treatment: update of possibilities for drug repurposing
VV Andrade Neto, EF Cunha Junior, VS Faioes… - 2018 - arca.fiocruz.br
The leishmaniases represent a public health problem in under-developed countries and are
considered a neglected disease by the World Health Organization (WHO). They are cuased …
considered a neglected disease by the World Health Organization (WHO). They are cuased …
Insights into the current status of privileged N-heterocycles as antileishmanial agents
Leishmania, one of the most important neglected tropical diseases, is endemic in several
regions of the world and hence regarded as a serious threat to public health. Major …
regions of the world and hence regarded as a serious threat to public health. Major …
Eugenia uniflora L. Essential Oil as a Potential Anti‐Leishmania Agent: Effects on Leishmania amazonensis and Possible Mechanisms of Action
KAF Rodrigues, LV Amorim… - Evidence‐Based …, 2013 - Wiley Online Library
Eugenia uniflora L. is a member of the Myrtaceae family and is commonly known as
Brazilian cherry tree. In this study, we evaluated the chemical composition of Eugenia …
Brazilian cherry tree. In this study, we evaluated the chemical composition of Eugenia …
Novel gold (I) complexes with 5-phenyl-1, 3, 4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents
JDS Chaves, LG Tunes, CHJ Franco… - European Journal of …, 2017 - Elsevier
The current anticancer and antileishmanial drug arsenal presents several limitations
concerning their specificity, efficacy, costs and the emergence of drug-resistant cells lines …
concerning their specificity, efficacy, costs and the emergence of drug-resistant cells lines …
Copper (I)‐Thiosemicarbazone Complexes with Dual Anticancer and Antiparasitic Activity
JF Machado, F Marques, T Pinheiro… - …, 2023 - Wiley Online Library
Four new Cu (I) complexes of the general formula [Cu (PP)(LL)][BF4], in which PP is a
phosphane ligand (triphenylphosphane or 1, 2‐bis (diphenylphosphano) ethane (dppe)) …
phosphane ligand (triphenylphosphane or 1, 2‐bis (diphenylphosphano) ethane (dppe)) …
Synthesis, characterization, and antileishmanial activity of neutral N-heterocyclic carbenes gold (I) complexes
C Zhang, SB Delmas, ÁF Álvarez, A Valentin… - European journal of …, 2018 - Elsevier
A series of five new mononuclear neutral gold (I) complexes containing N-heterocyclic
carbenes (NHCs) was synthesized and fully characterized by spectroscopic methods. The X …
carbenes (NHCs) was synthesized and fully characterized by spectroscopic methods. The X …
[HTML][HTML] Parasite and cancer relationship
Cancer is a life-threatening disease that occurs as a result of the uncontrolled proliferation of
cells in any organ or tissue of the body. Parasites are dangerous organisms that can cause …
cells in any organ or tissue of the body. Parasites are dangerous organisms that can cause …
Chemical composition and in vitro leishmanicidal, antibacterial and cytotoxic activities of essential oils of the Myrtaceae family occurring in the Cerrado biome
VP da Silva, CCF Alves, MLD Miranda… - Industrial Crops and …, 2018 - Elsevier
The essential oils of Eugenia uniflora L.(EuEO), Plinia cauliflora (Mart.)(PcEO) and
Syzygium cumini (L.)(ScEO), of the Myrtaceae family, were analyzed in gas chromatography …
Syzygium cumini (L.)(ScEO), of the Myrtaceae family, were analyzed in gas chromatography …
Synthesis of 4-aminoquinoline analogues and their platinum (II) complexes as new antileishmanial and antitubercular agents
AML Carmo, FMC Silva, PA Machado… - Biomedicine & …, 2011 - Elsevier
Abstract A series of 4-amino-7-chloroquinoline derivatives were synthesized by the reaction
of 4, 7-dichloro-quinoline with the corresponding diamine and then with propargyl bromide …
of 4, 7-dichloro-quinoline with the corresponding diamine and then with propargyl bromide …
Mahanine exerts in vitro and in vivo antileishmanial activity by modulation of redox homeostasis
Earlier we have established a carbazole alkaloid (mahanine) isolated from an Indian edible
medicinal plant as an anticancer agent with minimal effect on normal cells. Here we report …
medicinal plant as an anticancer agent with minimal effect on normal cells. Here we report …