The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

The annual number of cancer deaths continues increasing every day; thus, it is urgent to
search for and find active, selective, and efficient anticancer drugs as soon as possible …

On the basis of structures of known topoisomerase II catalytic inhibitors and initial molecular
docking studies, bicyclic N-fused aminoimidazoles were predicted as potential …

Xanthones are a class of oxygen containing heterocyclic compounds with a broad range of
biological activities, and they have prominent significance in the field of medicinal chemistry …

Evodiamine is a quinazolinocarboline alkaloid isolated from the fruits of traditional Chinese
herb Evodiae fructus. Previously, we identified N13-substituted evodiamine derivatives as …

A series of novel terpyridine-skeleton molecules containing conformational rigidity, 14
containing benzo [4, 5] furo [3, 2-b] pyridine core and 15 comprising chromeno [4, 3-b] …

A series of novel xanthone conjugated amino acids were synthesised and characterised by
analytical and spectroscopic methods. All the synthesized analogues (2–23) were screened …

Due to the high mortality rate in India, the identification of novel molecules is important in the
development of novel and potent anticancer drugs. Xanthones are natural constituents of …

We have designed and synthesized a series of 2, 4, 6-triaryl pyridine derivatives containing
chlorophenyl and phenolic moeity at 2-and 4-position of the central pyridine, respectively …

DNA topoisomerase II (TOP2) is a wellknown anticancer target. Its inhibitors are among the
most effective anticancer drugs currently in clinical use. TOP2-targeting agents fall into two …