Diagonal earlobe crease (Frank's sign) and increased risk of cerebrovascular diseases: review of the literature and implications for clinical practice

F Pacei, A Bersano, F Brigo, S Reggiani… - Neurological …, 2020 - Springer
Diagonal earlobe crease (DELC) or Frank's sign is a diagonal crease in the earlobe that
extends diagonally from the tragus to the edge of the auricle with an angle of approximately …

Patients with earlobe crease may associate with lower concentration of the age-suppressing hormone Klotho

J Wang, ZF Zhu, FQ Liu, C Liu… - … Journal of General …, 2021 - Taylor & Francis
Objective Earlobe crease (ELC) has been considered as a skin sign of atherosclerosis, and
its pathophysiological mechanism is still unclear. Our study aims to test the hypothesis that …

Inflammation beats cholesterol: a comment on the unequivocal driver of Cardiovascular Disease Risk

M Vaccarezza, FM Galassi - Journal of Clinical Medicine, 2023 - mdpi.com
Despite advancements in the current standard of care, cardiovascular diseases continue to
hold the top spot as the leading cause of mortality worldwide. The development of …

The prognostic value of deep earlobe creases in patients with acute ischemic stroke

J Xu, L Wang, C Zhang, J Wang, D Zheng… - Frontiers in …, 2023 - frontiersin.org
Background and purpose Data on earlobe crease (ELC) among patients with acute ischemic
stroke (AIS) are limited. Here, we determined the frequency and characteristics of ELC and …

[HTML][HTML] Unified anatomical explanation of diagonal earlobe creases, preauricular creases, and paired creases of the helix

M Abrahim - Cureus, 2022 - ncbi.nlm.nih.gov
Three types of ear creases have been described in the medical literature in association with
several cardiovascular and metabolic disorders: diagonal earlobe creases (DELCs)(Frank's …

The importance of inspection in clinical cardiology: Frank's sign

G Bazoukis, SS Papadatos, D Varrias… - Clinical Case …, 2022 - Wiley Online Library
The Frank's sign (FS) is a diagonal earlobe crease running from the tragus to the edge of the
auricle. In this case, we describe a 71 years‐old male patient with FS who presented to the …

Horton's disease in Michelangelo Buonarroti (1475–1564): the origin of his neurological debilitations in old age

D de Campos - Neurological Sciences, 2023 - Springer
Background Based on portraits of the time, this description provides novel evidence that the
celebrated Renaissance artist and genius of human anatomy, Michelangelo Buonarroti …

An iconodiagnosis for Joos Vijd, as painted by the van Eycks in the Ghent Altarpiece

B Lefrère, JB Arlet, J Pouchot - Neurological Sciences, 2024 - Springer
Abstract The Ghent Altarpiece, a jewel of Gothic art painted by the van Eyck brothers in the
fifteenth century, is particularly noteworthy for its use of an innovative dilution of oil, giving it …

[HTML][HTML] Диагональная складка мочки уха и ишемическая болезнь сердца

ИД Кароматов, Д Зиеев - Биология и интегративная медицина, 2022 - cyberleninka.ru
В статье приведен обзор литературы по исследованию значения диагностического
знака-диагональной складки мочки уха-знака Фрэнка в диагностике заболеваниям …

Reply to Baudouin and Simon:" The Medici earlobe crease".

FM Galassi, D Lippi, R Bianucci - European Annals of …, 2021 - europepmc.org
Reply to Baudouin and Simon: "The Medici earlobe crease". - Abstract - Europe PMC Sign in |
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