Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …

Drug-resistant tuberculosis (DR-TB) remains a global crisis due to the increasing incidence
of drug-resistant forms of the disease, gaps in detection and prevention, models of care, and …

Tuberculosis (TB) recently became the leading infectious cause of death in adults, while
attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance …

Rationale: Acquired resistance is an important driver of multidrug-resistant tuberculosis (TB),
even with good treatment adherence. However, exactly what initiates the resistance and …

Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH< 5.8) and is thought
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …

Model‐informed drug development (MIDD) has a long and rich history in infectious
diseases. This review describes foundational principles of translational anti‐infective …

The success of Mycobacterium tuberculosis (Mtb) is largely attributed to its ability to
physiologically adapt and withstand diverse localized stresses within host …

Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the
course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often …

Inclusion of pyrazinamide (PZA) in the tuberculosis (TB) drug regimen during the 1970s
enabled a reduction in treatment duration from 12 to 6 months. PZA has this remarkable …