Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The endothelial barrier consists of intercellular contacts localized in the cleft between
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …

The barrier properties of endothelial cells are critical for the maintenance of water and
protein balance between the intravascular and extravascular compartments. An impairment …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Actomyosin contractility affects cellular organization within tissues in part through the
generation of mechanical forces at sites of cell–matrix and cell–cell contact. While increased …

Extracellular matrix (ECM) is essential for all stages of angiogenesis. In the adult,
angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement …

Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions.
These junctional complexes are related to those found at epithelial junctions but with …

Inflammatory mediators increase vascular permeability primarily by formation of intercellular
gaps between endothelial cells of post-capillary venules. Under these conditions …

Endothelial cells receive multiple information from their environment that eventually leads
them to progress along all the stages of the process of formation of new vessels. Angiogenic …