Stroke is the second leading cause of death and the third leading cause of disability
worldwide and its burden is increasing rapidly in low-income and middle-income countries …

Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Background Whether chlorthalidone is superior to hydrochlorothiazide for preventing major
adverse cardiovascular events in patients with hypertension is unclear. Methods In a …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Background Resistant hypertension is associated with increased cardiovascular risk. The
endothelin pathway has been implicated in the pathogenesis of hypertension, but it is …

As the leading cause of death worldwide, cardiovascular diseases (CVDs) present major
challenges for health systems. In this study, we analyzed the effects of better population …

Chronic kidney disease (CKD) is defined by a low glomerular filtration rate or high
albuminuria, and affects 15–20% of adults globally. CKD increases the risk of various …

High systolic blood pressure (SBP) is a major risk factor for ischemic heart disease (IHD), the
leading cause of death worldwide. Using data from published observational studies and …

Objective To perform a large-scale pairwise and network meta-analysis on the effects of all
relevant exercise training modes on resting blood pressure to establish optimal …

Hypertension is a worldwide problem with major impacts on health including morbidity and
mortality, as well as consumption of health care resources. Nearly 50% of American adults …