Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

Guidelines for the use of flow cytometry and cell sorting in immunological studies*

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2017 - Wiley Online Library
From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Single-cell bioluminescence imaging of deep tissue in freely moving animals

S Iwano, M Sugiyama, H Hama, A Watakabe… - Science, 2018 - science.org
Bioluminescence is a natural light source based on luciferase catalysis of its substrate
luciferin. We performed directed evolution on firefly luciferase using a red-shifted and highly …

Human mesenchymal stem cells-current trends and future prospective

I Ullah, RB Subbarao, GJ Rho - Bioscience reports, 2015 - portlandpress.com
Stem cells are cells specialized cell, capable of renewing themselves through cell division
and can differentiate into multi-lineage cells. These cells are categorized as embryonic stem …

Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application

H Caplan, SD Olson, A Kumar, M George… - Frontiers in …, 2019 - frontiersin.org
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Umbilical cord-derived mesenchymal stem cell-derived exosomal microRNAs suppress myofibroblast differentiation by inhibiting the transforming growth factor-β …

S Fang, C Xu, Y Zhang, C Xue, C Yang… - Stem cells …, 2016 - academic.oup.com
Excessive scar formation caused by myofibroblast aggregations is of great clinical
importance during skin wound healing. Studies have shown that mesenchymal stem cells …

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives

S Regmi, S Pathak, JO Kim, CS Yong… - European journal of cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

[HTML][HTML] Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis

R Kramann, RK Schneider, DP DiRocco, F Machado… - Cell stem cell, 2015 - cell.com
Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including
kidney, lung, liver, and heart, although their roles in these tissues are poorly understood …

Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury

G Thomi, D Surbek, V Haesler… - Stem cell research & …, 2019 - Springer
Background Preterm newborns are at high risk of developing neurodevelopmental deficits
caused by neuroinflammation leading to perinatal brain injury. Human Wharton's jelly …