Some prospective alternatives for treating pain: the endocannabinoid system and its putative receptors GPR18 and GPR55

R Guerrero-Alba, P Barragán-Iglesias… - Frontiers in …, 2019 - frontiersin.org
Background: Marijuana extracts (cannabinoids) have been used for several millennia for
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …

Novel bioactive glycerol-based lysophospholipids: new data–new insight into their function

A Grzelczyk, E Gendaszewska-Darmach - Biochimie, 2013 - Elsevier
Based on the results of research conducted over last two decades, lysophospholipids (LPLs)
were observed to be not only structural components of cellular membranes but also …

Minireview: recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55

CM Henstridge, NAB Balenga, J Kargl… - Molecular …, 2011 - academic.oup.com
Emerging data suggest that off-target cannabinoid effects may be mediated via novel seven-
transmembrane spanning/G protein-coupled receptors. Due to its cannabinoid sensitivity …

Lysophosphatidylinositols, from cell membrane constituents to GPR55 ligands

M Alhouayek, J Masquelier, GG Muccioli - Trends in pharmacological …, 2018 - cell.com
Lysophosphatidylinositols (LPIs) are membrane constituents that alter the properties of said
membranes. However, recent data showing that the once orphan receptor, GPR55, can act …

Lysophosphatidylinositol signalling: new wine from an old bottle

R Piñeiro, M Falasca - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
Lysophosphatidylinositol (LPI) is a bioactive lipid generated by phospholipase A2 which is
believed to play an important role in several diseases. Indeed LPI can affect various …

[HTML][HTML] Lysolecithin as feed additive enhances collagen expression and villus length in the jejunum of broiler chickens

DL Brautigan, R Li, E Kubicka, SD Turner, JS Garcia… - Poultry Science, 2017 - Elsevier
Adding lysolecithin to feed has reportedly improved the performance of broiler chickens.
Lysolecithin is generated by phospholipase catalyzed hydrolysis of lecithin. The enzymatic …

[HTML][HTML] Lysophosphatidylinositol signalling and metabolic diseases

SA Arifin, M Falasca - Metabolites, 2016 - mdpi.com
Metabolism is a chemical process used by cells to transform food-derived nutrients, such as
proteins, carbohydrates and fats, into chemical and thermal energy. Whenever an alteration …

GPR55‐dependent stimulation of insulin secretion from isolated mouse and human islets of L angerhans

B Liu, S Song, I Ruz-Maldonado… - Diabetes, Obesity …, 2016 - Wiley Online Library
Aims The novel cannabinoid receptor GPR55 is expressed by rodent islets and it has been
implicated in β‐cell function in response to a range of ligands. This study evaluated the …

GPR55: from orphan to metabolic regulator?

B Liu, S Song, PM Jones, SJ Persaud - Pharmacology & therapeutics, 2015 - Elsevier
GPR55 belongs to the class A family of G-protein coupled receptor (GPCRs) and its activity
is regulated by a range of synthetic and endogenous cannabinoids, and by lipid-derived …

[图书][B] The endocannabinoidome: the world of endocannabinoids and related mediators

V Di Marzo, J Wang - 2014 - books.google.com
The Endocannabinoidome: The World of Endocannabinoids and Related Mediators is
dedicated to the latest research and studies on endocannabinoids and cannabinoid …