Pharmacokinetic characteristics of long-acting injectable antipsychotics for schizophrenia: an overview
CU Correll, E Kim, JK Sliwa, W Hamm, S Gopal… - CNS drugs, 2021 - Springer
The availability of long-acting injectable (LAI) antipsychotics for the treatment of
schizophrenia provides clinicians with options that deliver continuous drug exposure and …
schizophrenia provides clinicians with options that deliver continuous drug exposure and …
[HTML][HTML] Personalizing dosing of risperidone, paliperidone and clozapine using therapeutic drug monitoring and pharmacogenetics
J de Leon - Neuropharmacology, 2020 - Elsevier
By combining knowledge of pharmacogenetics, therapeutic drug monitoring (TDM) and drug-
drug interactions (DDIs) the author developed a model for personalizing antipsychotic …
drug interactions (DDIs) the author developed a model for personalizing antipsychotic …
A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting risperidone
G Schoretsanitis, E Spina, C Hiemke… - Expert review of clinical …, 2017 - Taylor & Francis
Introduction: This systematic review of therapeutic drug monitoring (TDM) identifies three
long-acting injectable (LAI) risperidone formulations. Areas covered: Limited data is …
long-acting injectable (LAI) risperidone formulations. Areas covered: Limited data is …
Population pharmacokinetic modeling after repeated administrations of RBP‐6000, a new, subcutaneously injectable, long‐acting, sustained‐release formulation of …
CM Laffont, R Gomeni, C Heidbreder… - The Journal of …, 2016 - Wiley Online Library
RBP‐6000 is a novel sustained‐release formulation of buprenorphine for the treatment of
opioid use disorder, which has been designed for once‐monthly (28 days) subcutaneous …
opioid use disorder, which has been designed for once‐monthly (28 days) subcutaneous …
Population pharmacokinetics of a monthly buprenorphine depot injection for the treatment of opioid use disorder: a combined analysis of phase II and phase III trials
AK Jones, E Ngaimisi, M Gopalakrishnan… - Clinical …, 2021 - Springer
Abstract Background BUP-XR (aka RBP-6000 or SUBLOCADE™) is an extended-release
subcutaneous buprenorphine formulation for the treatment of opioid use disorder. BUP-XR …
subcutaneous buprenorphine formulation for the treatment of opioid use disorder. BUP-XR …
[HTML][HTML] The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate …
N Darville, M van Heerden, D Mariën… - Journal of Controlled …, 2016 - Elsevier
The intramuscular (IM) administration of long-acting injectable (LAI) aqueous nano-
/microsuspensions elicits a chronic granulomatous injection site reaction, which recently has …
/microsuspensions elicits a chronic granulomatous injection site reaction, which recently has …
Efficacy, safety, and tolerability of RBP-7000 once-monthly risperidone for the treatment of acute schizophrenia: an 8-week, randomized, double-blind, placebo …
AF Nasser, DC Henderson, M Fava… - Journal of clinical …, 2016 - journals.lww.com
RBP-7000 is a sustained-release formulation of risperidone for the treatment of
schizophrenia, designed to be administered by once-monthly subcutaneous injection using …
schizophrenia, designed to be administered by once-monthly subcutaneous injection using …
Sustained delivery formulations of risperidone compounds
E Dadey, Q Li, C Lindemann - US Patent 10,010,612, 2018 - Google Patents
Xia et al.(“Uniform biodegradable microparticle systems for con trolled release” in J.
Controlled Release Jul. 18, 2002;(82 (1): 137-147).* Fleischhacker et al.“Treatment of …
Controlled Release Jul. 18, 2002;(82 (1): 137-147).* Fleischhacker et al.“Treatment of …
Long-acting injectable antipsychotics update: lengthening the dosing interval and expanding the diagnostic indications
L Citrome - Expert Review of Neurotherapeutics, 2017 - Taylor & Francis
Introduction: Long-acting injectable (LAI) antipsychotics are a useful but underutilized option
in the management of schizophrenia. Areas covered: This is a narrative review of newer LAI …
in the management of schizophrenia. Areas covered: This is a narrative review of newer LAI …
[HTML][HTML] Application of pharmacometrics in drug development
Y Xiong, MN Samtani, D Ouellet - Advanced Drug Delivery Reviews, 2024 - Elsevier
The last two decades have witnessed profound changes in how advanced computational
tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost …
tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost …