Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …

Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

All movements are generated by the activation of motoneurons, and hence their input-output
properties define the final step in processing of all motor commands. A major challenge to …

Objective Dravet syndrome is a severe form of intractable pediatric epilepsy with a high
incidence of SUDEP: S udden U nexpected D eath in epilepsy. Cardiac arrhythmias are a …

Variants in the SCN 2A gene, encoding the voltage‐gated sodium channel NaV1. 2, cause a
variety of neuropsychiatric syndromes with different severity ranging from self‐limiting …

Abstract In 2012, Tetrodotoxin (TTX) was identified in mussels and linked to the presence of
Prorocentrum minimum (P. minimum) in Greece. The connexion between TTX and P …

Background Oxaliplatin, a platinum-based chemotherapy utilised in the treatment of
colorectal cancer, produces two forms of neurotoxicity-acute sensorimotor neuropathic …

The size principle underlies the orderly recruitment of motor units; however, motoneuron
size is a poor predictor of recruitment amongst functionally defined motoneuron subtypes …

Key points Inputs impinging on layer 5 pyramidal neurons perform essential operations as
these cells represent one of the most important output carriers of the cerebral cortex …

Pathogenic variants in the voltage-gated sodium channel gene (SCN1A) are amongst the
most common genetic causes of childhood epilepsies. There is considerable heterogeneity …