Ultrafast water permeation through nanochannels with a densely fluorous interior surface

Y Itoh, S Chen, R Hirahara, T Konda, T Aoki, T Ueda… - Science, 2022 - science.org
Ultrafast water permeation in aquaporins is promoted by their hydrophobic interior surface.
Polytetrafluoroethylene has a dense fluorine surface, leading to its strong water repellence …

Guanidinium-based “molecular glues” for modulation of biomolecular functions

R Mogaki, PK Hashim, K Okuro, T Aida - Chemical Society Reviews, 2017 - pubs.rsc.org
Molecular adhesion based on multivalent interactions plays essential roles in various
biological processes. Hence,“molecular glues” that can adhere to biomolecules may …

Cellular uptake of substrate-initiated cell-penetrating poly (disulfide) s

G Gasparini, EK Bang, G Molinard… - Journal of the …, 2014 - ACS Publications
Substrate-initiated, self-inactivating, cell-penetrating poly (disulfide) s (siCPDs) are
introduced as general transporters for the covalent delivery of unmodified substrates of free …

Light-and electric-field-controlled wetting behavior in nanochannels for regulating nanoconfined mass transport

G Xie, P Li, Z Zhao, Z Zhu, XY Kong… - Journal of the …, 2018 - ACS Publications
Water wetting behavior in nanoconfined environments plays an important role in mass
transport and signal transmission of organisms. It is valuable and challenging to investigate …

Linear versus dendritic molecular binders for hydrogel network formation with clay nanosheets: studies with ABA triblock copolyethers carrying guanidinium ion …

S Tamesue, M Ohtani, K Yamada, Y Ishida… - Journal of the …, 2013 - ACS Publications
ABA-triblock copolyethers 1a–1c as linear polymeric binders, in combination with clay
nanosheets (CNSs), afford high-water-content moldable supramolecular hydrogels with …

Light-responsive nanochannels based on the supramolecular host–guest system

J Quan, Y Guo, J Ma, D Long, J Wang, L Zhang… - Frontiers in …, 2022 - frontiersin.org
The light-responsive nanochannel of rhodopsin gained wider research interest from its
crucial roles in light-induced biological functions, such as visual signal transduction and …

Reductively cleavable nanocaplets for siRNA delivery by template-assisted oxidative polymerization

PK Hashim, K Okuro, S Sasaki… - Journal of the American …, 2015 - ACS Publications
A series of water-soluble telechelic dithiol monomers bearing multiple guanidinium ion
(Gu+) units in their main chains were synthesized for packaging siRNA by template-assisted …

Transferrin-appended nanocaplet for transcellular siRNA delivery into deep tissues

A Kohata, PK Hashim, K Okuro… - Journal of the American …, 2019 - ACS Publications
Transferrin (Tf) is known to induce transcytosis, which is a consecutive endocytosis/
exocytosis event. We developed a Tf-appended nanocaplet (TfNC⊃ siRNA) for the purpose …

Intracellular photoactivation of caspase-3 by molecular glues for spatiotemporal apoptosis induction

NB Hentzen, R Mogaki, S Otake… - Journal of the American …, 2020 - ACS Publications
Caspase-3 (Casp-3) is an enzyme that efficiently induces apoptosis, a form of programmed
cell death. We report a dendritic molecular glue PCGlue that enables intracellular delivery of …

Adhesive photoswitch: selective photochemical modulation of enzymes under physiological conditions

R Mogaki, K Okuro, T Aida - Journal of the American Chemical …, 2017 - ACS Publications
We developed a water-soluble adhesive photoswitch (Glue n-Azo-SA, average n= 5) that
selectively binds to a target enzyme and photochemically modulates its enzymatic activity …