Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …

Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …

Antibodies and Fc-fusion antibody-like proteins have become successful biologics
developed for cancer treatment, passive immunity against infection, addiction, and …

Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma
receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …

Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …