[HTML][HTML] PLGA-based nanomedicines manufacturing: Technologies overview and challenges in industrial scale-up

MC Operti, A Bernhardt, S Grimm, A Engel… - International Journal of …, 2021 - Elsevier
Nanomedicines based on poly (lactic-co-glycolic acid)(PLGA) carriers offer tremendous
opportunities for biomedical research. Although several PLGA-based systems have already …

Topical drug delivery: History, percutaneous absorption, and product development

MS Roberts, HS Cheruvu, SE Mangion… - Advanced drug delivery …, 2021 - Elsevier
Topical products, widely used to manage skin conditions, have evolved from simple potions
to sophisticated delivery systems. Their development has been facilitated by advances in …

Assessing and predicting physical stability of emulsion-based topical semisolid products: a review

AZM Badruddoza, T Yeoh, JC Shah, T Walsh - Journal of Pharmaceutical …, 2023 - Elsevier
The emulsion-based topical semisolid dosage forms present a high degree of complexity
due to their microstructures which is apparent from their compositions comprising at least …

Rheology by design: A regulatory tutorial for analytical method validation

A Simões, M Miranda, C Cardoso, F Veiga, C Vitorino - Pharmaceutics, 2020 - mdpi.com
The increasing demand for product and process understanding as an active pursuit in the
quality guideline Q8 and, more recently, on the draft guideline on quality and equivalence of …

Transdermal Drug Delivery Systems (TDDS): recent advances and failure modes

M Ghaferi, SE Alavi, K Phan, H Maibach… - Molecular …, 2024 - ACS Publications
Transdermal drug delivery systems (TDDS), commonly refered to as" patches", present a
nonintrusive technique to provide medication without the need for invasive procedures …

Viscoelastic and deformation characteristics of structurally different commercial topical systems

M Dabbaghi, S Namjoshi, B Panchal, JE Grice… - Pharmaceutics, 2021 - mdpi.com
Rheological characteristics and shear response have potential implication in defining the
pharmaceutical equivalence, therapeutic equivalence, and perceptive equivalence of …

Topical caffeine-loaded nanostructured lipid carriers for enhanced treatment of cellulite: A 32 full factorial design optimization and in vivo evaluation in rats

AA Kassem, MH Asfour, SH Abd El-Alim… - International Journal of …, 2023 - Elsevier
The goal of this study was the development and evaluation of semisolid caffeine (CAF)
loaded nanostructured lipid carriers (NLCs) for topical treatment of cellulite. CAF-loaded …

The implications of regulatory framework for topical semisolid drug products: From critical quality and performance attributes towards establishing bioequivalence

T Ilić, I Pantelić, S Savić - Pharmaceutics, 2021 - mdpi.com
Due to complex interdependent relationships affecting their microstructure, topical semisolid
drug formulations face unique obstacles to the development of generics compared to other …

Polyaphron dispersion technology, a novel topical formulation and delivery system combining drug penetration, local tolerability and convenience of application

M Praestegaard, F Steele, N Crutchley - Dermatology and Therapy, 2022 - Springer
Topical formulation and delivery technologies for pharmaceutical application should
simultaneously address efficacy, safety and convenience of therapy. This has historically …

Rational design of topical semi-solid dosage forms-how far are we?

ME Herbig, DH Evers, S Gorissen, M Köllmer - Pharmaceutics, 2023 - mdpi.com
Specific aspects of semi-solid dosage forms for topical application include the nature of the
barrier to be overcome, aspects of susceptibility to physical and chemical instability, and a …