Background: Previous guidelines for the management of thyroid nodules and cancers were
geared toward adults. Compared with thyroid neoplasms in adults, however, those in the …

Abstract Fibrous Dysplasia/McCune Albright syndrome (FD/MAS) represents a wide
spectrum of diseases due to somatic gain-of-function mutations of the GNAS gene. The …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Abstract Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare disorder of
striking complexity. It arises from somatic, gain-of-function mutations in GNAS, leading to …

Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent
advances have improved our understanding of its pathogenesis; these include the …

McCune-Albright syndrome (MAS) is classically defined by the clinical triad of fibrous
dysplasia of bone (FD), café-au-lait skin spots, and precocious puberty (PP). It is a rare …

Fibrous dysplasia (FD) is sometimes accompanied by extraskeletal manifestations that can
include any combination of café-au-lait macules, hyperfunctioning endocrinopathies, such …

Fibrous dysplasia/McCune-Albright syndrome (FD/MAS), the result of an early embryonic
postzygotic somatic activating pathogenic variant in GNAS (encoding the cAMP pathway …

Fibrous dysplasia (FD) is a rare bone disease caused by postzygotic somatic activating
mutations in the GNAS gene, which lead to constitutive activation of adenylyl cyclase and …

Fibrous dysplasia (FD) is an uncommon and debilitating skeletal disorder resulting in
fractures, deformity, functional impairment, and pain. It arises from post-zygotic somatic …