Traveling with purpose: cell-to-cell transport of plant mRNAs
Messenger RNAs (mRNAs) in multicellular organisms can act as signals transported cell-to-
cell and over long distances. In plants, mRNAs traffic cell-to-cell via plasmodesmata (PDs) …
cell and over long distances. In plants, mRNAs traffic cell-to-cell via plasmodesmata (PDs) …
Caspases help to spread the message via extracellular vesicles
Cell‐cell communication is an essential aspect of multicellular life, key for coordinating cell
proliferation, growth, and death in response to environmental changes. Whilst caspases are …
proliferation, growth, and death in response to environmental changes. Whilst caspases are …
Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels
Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow,
where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We …
where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We …
Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina
Background The discovery of material transfer between transplanted and host mouse
photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as …
photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as …
Invisible Bridges: Unveiling the Role and Prospects of Tunneling Nanotubes in Cancer Therapy
M Chen, D Zhao - Molecular Pharmaceutics, 2024 - ACS Publications
Tunneling nanotubes (TNTs) are essential intercellular communication channels that
significantly impact cancer pathophysiology, affecting tumor progression and resistance …
significantly impact cancer pathophysiology, affecting tumor progression and resistance …
Re-analysis of mobile mRNA datasets highlights challenges in the detection of mobile transcripts from short-read RNA-Seq data
P Paajanen, M Tomkins, F Hoerbst, R Veevers… - bioRxiv, 2024 - biorxiv.org
Short-read RNA-Seq analyses of grafted plants have led to the proposal that large numbers
of mRNAs move over long distances between plant tissues, acting as potential signals. The …
of mRNAs move over long distances between plant tissues, acting as potential signals. The …
Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State
Inter-cellular transmission of mRNA is being explored in mammalian species using immortal
cell lines (1–3). Here, we uncover an inter-cellular mRNA transfer phenomenon that allows …
cell lines (1–3). Here, we uncover an inter-cellular mRNA transfer phenomenon that allows …
Evidence for in vivo mRNA Transport Between Mammalian Cells
The prevalence and significance of intercellular mRNA transport remains unknown. Direct
detection of mRNA transfer between cells within an organism is challenging due to technical …
detection of mRNA transfer between cells within an organism is challenging due to technical …
Complementation of a human disease phenotype in vitro by intercellular mRNA transfer
There is growing evidence that full-length mRNAs undergo intercellular transfer through
long, thin cytoplasmic connections called tunneling nanotubes (TNTs), but whether …
long, thin cytoplasmic connections called tunneling nanotubes (TNTs), but whether …
Conservation of mRNA operon formation in the control of the heat shock response in mammalian cells
E Pataki, JE Gerst - bioRxiv, 2024 - biorxiv.org
Prokaryotic organisms rely on polycistronic transcription (ie operons) to express multiple
mRNAs from a single promoter, enabling rapid and robust responses to stimuli. In yeast, a …
mRNAs from a single promoter, enabling rapid and robust responses to stimuli. In yeast, a …