Traveling with purpose: cell-to-cell transport of plant mRNAs

M Kitagawa, TM Tran, D Jackson - Trends in Cell Biology, 2024 - cell.com
Messenger RNAs (mRNAs) in multicellular organisms can act as signals transported cell-to-
cell and over long distances. In plants, mRNAs traffic cell-to-cell via plasmodesmata (PDs) …

Caspases help to spread the message via extracellular vesicles

C Hill, ER Dellar, LA Baena‐Lopez - The FEBS Journal, 2023 - Wiley Online Library
Cell‐cell communication is an essential aspect of multicellular life, key for coordinating cell
proliferation, growth, and death in response to environmental changes. Whilst caspases are …

Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels

S Sinha, BW Callow, AP Farfel, S Roy, S Chen… - The Journal of Clinical …, 2024 - jci.org
Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow,
where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. We …

Transplanted human photoreceptors transfer cytoplasmic material but not to the recipient mouse retina

MT Ho, K Kawai, D Abdo, L Comanita… - Stem Cell Research & …, 2024 - Springer
Background The discovery of material transfer between transplanted and host mouse
photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as …

Invisible Bridges: Unveiling the Role and Prospects of Tunneling Nanotubes in Cancer Therapy

M Chen, D Zhao - Molecular Pharmaceutics, 2024 - ACS Publications
Tunneling nanotubes (TNTs) are essential intercellular communication channels that
significantly impact cancer pathophysiology, affecting tumor progression and resistance …

Re-analysis of mobile mRNA datasets highlights challenges in the detection of mobile transcripts from short-read RNA-Seq data

P Paajanen, M Tomkins, F Hoerbst, R Veevers… - bioRxiv, 2024 - biorxiv.org
Short-read RNA-Seq analyses of grafted plants have led to the proposal that large numbers
of mRNAs move over long distances between plant tissues, acting as potential signals. The …

Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State

Y Yoneyama, RR Zhang, M Kimura, Y Cai, M Adam… - …, 2024 - pmc.ncbi.nlm.nih.gov
Inter-cellular transmission of mRNA is being explored in mammalian species using immortal
cell lines (1–3). Here, we uncover an inter-cellular mRNA transfer phenomenon that allows …

Evidence for in vivo mRNA Transport Between Mammalian Cells

A Shubin, S Liu, G Church, CP Hunter - bioRxiv, 2024 - biorxiv.org
The prevalence and significance of intercellular mRNA transport remains unknown. Direct
detection of mRNA transfer between cells within an organism is challenging due to technical …

Complementation of a human disease phenotype in vitro by intercellular mRNA transfer

G Haimovich, S Dasgupta, AG Ravi, JE Gerst - bioRxiv, 2024 - biorxiv.org
There is growing evidence that full-length mRNAs undergo intercellular transfer through
long, thin cytoplasmic connections called tunneling nanotubes (TNTs), but whether …

Conservation of mRNA operon formation in the control of the heat shock response in mammalian cells

E Pataki, JE Gerst - bioRxiv, 2024 - biorxiv.org
Prokaryotic organisms rely on polycistronic transcription (ie operons) to express multiple
mRNAs from a single promoter, enabling rapid and robust responses to stimuli. In yeast, a …