The present review deals mainly with the ontogenesis of two important phenomena involved
in vulnerability to several neuropsychiatric disorders, namely with drug-induced sensitization …

Evidence is accumulating that the etiology, epidemiology, consequences and mechanisms
that underlie drug abuse are different in males and females. In this review, we present …

Treatment of attention deficit hyperactivity disorder with the psychostimulant drug
methylphenidate (MP) has increased dramatically among schoolchildren. We tested whether …

Drug abuse researchers have noted striking similarities between behaviors elicited by
Pavlovian sign-tracking procedures and prominent symptoms of drug abuse. In Pavlovian …

Use of addictive substances by human juveniles and adolescents is common, including use
to intoxication and progression from one drug to other drugs. Until quite recently, animal …

Rationale Ketamine is used by preadolescent and adolescent humans for licit and illicit
purposes. Objective The goal of the present study was to determine the effects of acute and …

Cocaine-induced increases in ventral striatal dopamine levels are enhanced in adult rats
previously exposed to chronic stress. In neonatal rats, isolation from dam, nest, and siblings …

Drug abuse during adolescence may predispose towards later adult substance abuse and
major depressive disorders (Brook et al., 2002). The purpose of the present study was to …

High doses of apomorphine induce sensitization to locomotor stimulant effects whereas low
doses induce locomotor inhibition. We examined whether repeated low dose apomorphine …

Sensitization is a common feature of psychostimulants and sensitization effects are
generally considered to be linked to the addictive properties of these drugs. We used a …