The invention provides in situ nucleic acid sequencing to be conducted in biological
specimens that have been physically expanded. The invention leverages the techniques for …

A nucleic acid sequencing method involving contacting a spatially defined target nucleic
acid sequence with N labeled oligonucleotide probes and performing measurements, at …

The invention enables in situ genomic and transcriptomic assessment of nucleic acids to be
conducted in biological specimens that have been physically expanded. The invention …

The invention provides a method termed protein retention ExM (proExM), in which proteins,
rather than labels, are anchored to the swellable gel, using a cross-linking molecule. This …

The present invention leverages the techniques for expansion microscopy (ExM) to provide
improved high-throughput super-resolution whole-organ imaging methodology to image …

The present invention provides methods for analyzing polynucleotides such as genomic
DNA. In some embodiments, the disclosure provides a method for preparing and amplifying …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
55963288&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

2005/0034990 Al 2005/0090016 A1 2005/0169962 A1 2005/0196702 A1 2006/0000767 Al
2006/0003356 A1 2006/0110760 Al 2006/0115146 Al 2006/0165912 A1 2007/0023942 A1 …

A method for spatially tagging nucleic acids of a biological specimen, including steps of (a)
providing a solid support comprising different nucleic acid probes that are randomly located …

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oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo …