Non‐coding RNAs: regulators of disease
For 50 years the term 'gene'has been synonymous with regions of the genome encoding
mRNAs that are translated into protein. However, recent genome‐wide studies have shown …
mRNAs that are translated into protein. However, recent genome‐wide studies have shown …
HITS‐CLIP: panoramic views of protein–RNA regulation in living cells
RB Darnell - Wiley Interdisciplinary Reviews: RNA, 2010 - Wiley Online Library
The study of gene regulation in cells has recently begun to shift from a period dominated by
the study of transcription factor‐DNA interactions to a new focus on RNA regulation. This …
the study of transcription factor‐DNA interactions to a new focus on RNA regulation. This …
Identification of RNA–protein interaction networks using PAR‐CLIP
All mRNA molecules are subject to some degree of post‐transcriptional gene regulation
(PTGR) involving sequence‐dependent modulation of splicing, cleavage and …
(PTGR) involving sequence‐dependent modulation of splicing, cleavage and …
Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline
Piwi proteins and Piwi‐interacting RNAs (piRNAs) repress transposition, regulate
translation, and guide epigenetic programming in the germline. Here, we show that an …
translation, and guide epigenetic programming in the germline. Here, we show that an …
Widespread expression of piRNA-like molecules in somatic tissues
Z Yan, HY Hu, X Jiang, V Maierhofer, E Neb… - Nucleic acids …, 2011 - academic.oup.com
Piwi-interacting RNA (piRNA) are small RNA abundant in the germline across animal
species. In fruit flies and mice, piRNA have been implicated in maintenance of genomic …
species. In fruit flies and mice, piRNA have been implicated in maintenance of genomic …
RNA–protein interactions in human health and disease
It is now clear that the genomes of many organisms encode thousands of large and small
non-coding (nc) RNAs. However, relative to the discovery of ncRNAs the functions and …
non-coding (nc) RNAs. However, relative to the discovery of ncRNAs the functions and …
Control of messenger RNA fate by RNA‐binding proteins: an emphasis on mammalian spermatogenesis
Posttranscriptional status of messenger RNAs (mRNA) can be affected by many factors,
most of which are RNA‐binding proteins (RBP) that either bind mRNA in a nonspecific …
most of which are RNA‐binding proteins (RBP) that either bind mRNA in a nonspecific …
Functional analysis of long noncoding RNAs in development and disease
Once viewed as part of the “dark matter” of genome, long noncoding RNAs (lncRNAs), which
are mRNA-like but lack open reading frames, have emerged as an integral part of the …
are mRNA-like but lack open reading frames, have emerged as an integral part of the …
The roles of the DAZ family in spermatogenesis: More than just translation?
MJW VanGompel, EY Xu - Spermatogenesis, 2011 - Taylor & Francis
The DAZ family of genes are important fertility factors in animals, including humans. The
family consists of Y-linked DAZ, and autosomal homologs Boule and Dazl. All three genes …
family consists of Y-linked DAZ, and autosomal homologs Boule and Dazl. All three genes …
Molecular functions of small regulatory noncoding RNA
Y Huang, JL Zhang, XL Yu, TS Xu, ZB Wang… - Biochemistry …, 2013 - Springer
Recently, using large-scale genomic sequencing, a great number of small noncoding RNAs
(ncRNA) has been discovered. Short ncRNAs can be classified into three major classes …
(ncRNA) has been discovered. Short ncRNAs can be classified into three major classes …