Rho GTPases regulate cytoskeletal and cell adhesion dynamics and thereby coordinate a
wide range of cellular processes, including cell migration, cell polarity and cell cycle …

Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

Defects in apoptosis regulation are one main cause of cancer development and may result
from overexpression of anti-apoptotic proteins such as inhibitor of apoptosis proteins (IAPs) …

Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …

Liquid droplet has emerged as a flexible intracellular compartment that modulates various
cellular processes. Here, we uncover an antimetastatic mechanism governed by the liquid …

Apoptosis is a tightly regulated cellular process and faulty regulation of apoptosis is a
hallmark of human cancers. Targeting key apoptosis regulators with the goal to restore …

Although technically a member of the Inhibitor of Apoptosis (IAP) gene family, survivin has
consistently defied assumptions, refuted predictions and challenged paradigms. Despite its …

Chemotherapy is a common strategy to treat cancer. However, acquired resistance and
metastasis are the major obstacles to successful treatment. Anastasis is a process by which …

Abnormal Rac1 signaling is linked to a number of debilitating human diseases, including
cancer, cardiovascular diseases and neurodegenerative disorders. As such, Rac1 …

Plant U-box type E3 ubiquitin ligases (PUBs) are well known for their functions in a variety of
stress responses, including immune responses and the adaptation to abiotic stresses. First …