The discovery of ferrocene,[Fe (η5-C5H5) 2], seventy years ago has significantly influenced
chemical research and provided a key impetus for establishing and rapidly expanding …

Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

Background Artefenomel (OZ439) is a novel synthetic trioxolane with improved
pharmacokinetic properties compared with other antimalarial drugs with the artemisinin …

Malaria and cancer are chronic diseases. The challenge with drugs available for the
treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent …

The revelation of the anticancer properties of cisplatin has inspired research into metal
complexes for the treatment of cancer. Several second and third generation cisplatin …

Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Hybrid molecules have the potential to enhance the efficacy against both drug-sensitive and
drug-resistant organisms, and Ferroquine, a ferrocene hybrid, has demonstrated great …

Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a
protozoan etiology, high incidence, and prevalence in developing countries. As a result …

The global challenge to the treatment of malaria is mainly the occurrence of resistance of
malaria parasites to conventionally used antimalarials. Artesunate, a semisynthetic …

Background Ferroquine (SSR97193) is a candidate anti-malarial currently undergoing
clinical trials for malaria. To better understand its pharmacokinetic (PK) and …