Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Fibroblast activation protein (FAP), a membrane-anchored peptidase, is highly expressed in
cancer-associated fibroblasts in more than 90% of epithelial tumors and contributes to …

IgG4-related disease (RD) is characterized by lymphoplasmacytic infiltration enriched in
IgG4-positive plasma cells and variable degrees of fibrosis with a characteristic storiform …

Integrins are transmembrane receptors that possess distinct ligand-binding specificities in
the extracellular domain and signaling properties in the cytoplasmic domain. While most …

Purpose Fibroblast activation protein (FAP) is a cell membrane–bound serine peptidase,
overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound …

Introduction 3. FAP expression and function in health and disease 3.1. FAP expression
under physiological conditions 3.2. FAP in non-malignant diseases 3.3. FAP in the tumor …

Background In rheumatoid arthritis (RA), fibroblast-like synoviocyte cells, which are involved
in inflammation of the articular cartilage and bone, overexpress fibroblast activation protein …

The impressive development of cancer immunotherapy in the last few years originates from
a more precise understanding of control mechanisms in the immune system leading to the …

The impact of inflammation on the outcome of many medical conditions such as
cardiovascular diseases, neurological disorders, infections, cancer, and autoimmune …

Background: Myocardial infarction (MI) evokes an organized remodeling process
characterized by the activation and transdifferentiation of quiescent cardiac fibroblasts to …