Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease, currently
affecting over 5 million Americans with projections expected to rise as the population ages …

Stroke has caused tremendous social stress worldwide, yet despite decades of research
and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue …

Background and Purpose: Neuronal pyroptosis is a type of regulated cell death triggered by
proinflammatory signals. CCR5 (CC chemokine receptor 5)-mediated inflammation is …

Bats are special in their ability to live long and host many emerging viruses. Our previous
studies showed that bats have altered inflammasomes, which are central players in aging …

Pyroptosis is a recently described mechanism of programmed cell death mediated by
proteins of the gasdermin family. Widely recognized signaling cascades include the …

Alzheimer's disease (AD) is the most common form of dementia, affecting more than 50
million people worldwide with an estimated increase to 139 million people by 2050. The …

Inflammasomes represent a group of protein complexes that contribute to host defense
against pathogens and repair processes upon the induction of inflammation. However …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that destroys memory
and cognitive function. Inflammasome activation has been suggested to play a critical role in …

Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect
microbial materials, sterile inflammatory insults, and certain host-derived elements …

Background Advanced age is a major risk factor for the development of many diseases
including those affecting the central nervous system. Wild-type isocitrate dehydrogenase …