A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

Pioneering gene therapy trials have shown that the genetic engineering of haematopoietic
stem and progenitor cells can be an alternative to allogeneic transplantation in the treatment …

Understanding the drivers and markers of clonally expanding HIV-1-infected CD4+ T cells is
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …

A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking
embryonic development through stepwise exposure to morphogens, or by conversion of one …

The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral
therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into …

X-linked severe combined immunodeficiency (SCID-X1) is a profound deficiency of T, B, and
natural killer (NK) cell immunity caused by mutations in IL2RG encoding the common chain …

Histone modifications regulate chromatin-dependent processes, yet the mechanisms by
which they contribute to specific outcomes remain unclear. H3K4me3 is a prominent histone …

Acute myeloid leukemia may be characterized by a fraction of leukemia stem cells (LSCs)
that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs …

A highly diverse T-cell receptor (TCR) repertoire is a fundamental property of an effective
immune system, and is associated with efficient control of viral infections and other …

Advancements in human genomics over the last two decades have shown that cancer is
mediated by somatic aberration in the host genome. This discovery has incited enthusiasm …