HLA‐C: an accomplice in rheumatic diseases

RJ Siegel, SL Bridges Jr, S Ahmed - ACR Open Rheumatology, 2019 - Wiley Online Library
Human leukocyte antigen c (HLA‐C) is a polymorphic membrane protein encoded by the
HLA‐C gene in the class I major histocompatibility complex. HLA‐C plays an essential role …

Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study

CL Martin, D Jima, GC Sharp, LE McCullough… - Epigenetics, 2019 - Taylor & Francis
Pre-pregnancy obesity is an established risk factor for adverse sex-specific cardiometabolic
health in offspring. Epigenetic alterations, such as in DNA methylation (DNAm), are a …

A 9 mRNAs-based diagnostic signature for rheumatoid arthritis by integrating bioinformatic analysis and machine-learning

J Liu, N Chen - Journal of Orthopaedic Surgery and Research, 2021 - Springer
Background Rheumatoid arthritis (RA) is an autoimmune rheumatic disease that carries a
substantial burden for both patients and society. Early diagnosis of RA is essential to prevent …

Global transcriptome analysis to identify critical genes involved in the pathology of osteoarthritis

X Zhang, Y Bu, B Zhu, Q Zhao, Z Lv, B Li… - Bone & Joint …, 2018 - boneandjoint.org.uk
Objectives The aim of this study was to identify key pathological genes in osteoarthritis (OA).
Methods We searched and downloaded mRNA expression data from the Gene Expression …

Genetic polymorphisms of ACE I/D, IL-1β G> A and IL-4 VNTR among Egyptian subjects with rheumatoid arthritis

RM Elshazli, AM Elsaid, DM Shawky… - Archives of Physiology …, 2022 - Taylor & Francis
Background Various reports examined the contribution of ACE I/D, IL-1β G> A and IL-4
VNTR with the susceptibility to RA but with conflicting findings. The goal of this study is to …

IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis

MSMA Damen, R Agca, S Holewijn, J de Graaf… - Scientific reports, 2017 - nature.com
Patients with rheumatoid arthritis (RA) are at higher risk of developing cardiovascular
diseases (CVD). Interleukin (IL)-32 has previously been shown to be involved in the …

Genetic variants associated with patent ductus arteriosus in extremely preterm infants

JM Dagle, KK Ryckman, CN Spracklen… - Journal of …, 2019 - nature.com
Objective: Patent ductus arteriosus (PDA) is a commonly observed condition in preterm
infants. Prior studies have suggested a role for genetics in determining spontaneous ductal …

Functional analysis of autoantibody signatures in rheumatoid arthritis

L Milchram, A Fischer, J Huber, R Soldo, D Sieghart… - Molecules, 2022 - mdpi.com
For the identification of antigenic protein biomarkers for rheumatoid arthritis (RA), we
conducted IgG profiling on high density protein microarrays. Plasma IgG of 96 human …

Grb7 protein RA domain oligomerization

MP Godamudunage, A Foster… - Journal of Molecular …, 2017 - Wiley Online Library
The growth factor receptor bound protein 7 (Grb7) is an adaptor protein that is often
coamplified with the erythroblastosis oncogene B 2 receptor in 20% to 30% of breast cancer …

Characterization of the full‐length human Grb7 protein and a phosphorylation representative mutant

AM Bradford, R Koirala, CK Park… - Journal of Molecular …, 2019 - Wiley Online Library
It is well known the dimerization state of receptor tyrosine kinases (RTKs), in conjunction
with binding partners such as the growth factor receptor bound protein 7 (Grb7) protein …