Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

E Parra, J Pérez-Gil - Chemistry and physics of lipids, 2015 - Elsevier
The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a
membrane-based system composed of multiple lipids and specific proteins, the primary …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

Regulation and repair of the alveolar-capillary barrier in acute lung injury

J Bhattacharya, MA Matthay - Annual review of physiology, 2013 - annualreviews.org
Considerable progress has been made in understanding the basic mechanisms that
regulate fluid and protein exchange across the endothelial and epithelial barriers of the lung …

Interactions of particulate matter and pulmonary surfactant: Implications for human health

F Wang, J Liu, H Zeng - Advances in colloid and interface science, 2020 - Elsevier
Particulate matter (PM), which is the primary contributor to air pollution, has become a
pervasive global health threat. When PM enters into a respiratory tract, the first body tissues …

The POOR Get POORer: a hypothesis for the pathogenesis of ventilator-induced lung injury

DP Gaver III, GF Nieman, LA Gatto… - American journal of …, 2020 - atsjournals.org
Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …

No ordinary proteins: Adsorption and molecular orientation of monoclonal antibodies

A Kanthe, A Ilott, M Krause, S Zheng, J Li, W Bu… - Science …, 2021 - science.org
The interaction of monoclonal antibodies (mAbs) with air/water interfaces plays a crucial role
in their overall stability in solution. We aim to understand this behavior using pendant bubble …

[图书][B] Colloid and interface science in pharmaceutical research and development

H Ohshima, K Makino - 2014 - books.google.com
Colloid and Interface Science in Pharmaceutical Research and Development describes the
role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed …

Effect of cholesterol nanodomains on monolayer morphology and dynamics

KH Kim, SQ Choi, ZA Zell, TM Squires… - Proceedings of the …, 2013 - National Acad Sciences
At low mole fractions, cholesterol segregates into 10-to 100-nm-diameter nanodomains
dispersed throughout primarily dipalmitoylphosphatidylcholine (DPPC) domains in mixed …

Evolution of interfacial mechanics of lung surfactant mimics progression of acute respiratory distress syndrome

CO Ciutara, SV Iasella, B Huang… - Proceedings of the …, 2023 - National Acad Sciences
How acute respiratory distress syndrome progresses from underlying disease or trauma is
poorly understood, and there are no generally accepted treatments resulting in a 40 …