Multidrug sensitivity is an autosomal recessive disorder in dogs caused by a 4-bp deletion in
the ABCB1 gene, often referred to as the ABCB1-1Δ variant. This disease has a high …

Materials and Methods: We clarified the prevalence of MDR1 nt230 (del4) in 263 dogs of
eight purebred dog breeds in Thailand using an allele-specific multiplex polymerase chain …

To date, a 4-bp deletion in the MDR1 gene has been detected in more than ten dog breeds,
as well as in mixed breed dogs, in several countries, however information regarding this …

The P-glycoprotein (P-gp) is a transmembrane protein encoded by the MDR1 gene that
functions as a biological barrier by extruding toxins and xenobiotics out of cells. The MDR1 …

This research aimed to investigate the sensitivity to the drug (ivermectin) in Kangal and
Akbaş breed dogs, which are dog breeds native to Turkey, via the MDR1 gene mutation. For …

A 4-bp deletion in the ATP-binding cassette subfamily B member 1 (ABCB1) gene, also
referred to as the multidrug resistance gene (MDR1), produces stop codons that cause …

O recurso a protocolos terapêuticos múltiplos em Medicina Veterinária é, tal como na
Medicina Humana, bastante frequente em regime hospitalar de cães e gatos …

Een 4-bp deletiemutatie in het ABCB1-gen–vroeger multidrug-resistentie gen–resulteert in
de vorming van een onvolledig P-glycoproteïne (P-gp). P-gp kent een belangrijke functie in …

Existen aproximadamente 700 enfermedades en caninos de origen genético de las cuales
solo el 30% tiene descripta la mutación causal. El incremento de la prevalencia de éstas se …

P-glycoprotein (ABCB1), the product of the Multidrug Resistance Gene (MDR1)(ABCB1)
gene, is the major multidrug transporter contributing to the barrier function of several tissues …