The proteasome is a highly sophisticated protease complex designed to carry out selective,
efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin …

The 26S proteasome is a highly conserved protein degradation machine that consists of the
20S proteasome and 19S regulatory particles, which include 14 and 19 different …

In this Opinion article, we aim to address how cells adapt to stress and the repercussions
chronic stress has on cellular function. We consider acute and chronic stress-induced …

In eukaryotic cells, degradation of most intracellular proteins is realized by proteasomes.
The substrates for proteolysis are selected by the fact that the gate to the proteolytic chamber …

The 26S proteasome is an enzymatic complex that degrades ubiquitinated proteins in
eukaryotic cells. It is composed of the 20S core particle (CP) and the 19S regulatory particle …

The 26S proteasome is a chambered protease in which the majority of selective cellular
protein degradation takes place. Throughout evolution, access of protein substrates to …

Modulation of endogenous cellular defense mechanisms via the stress response signaling
represents an innovative approach to therapeutic intervention in diseases causing chronic …

Aging is a natural biological process that is characterized by a progressive accumulation of
macromolecular damage. In the proteome, aging is accompanied by decreased protein …

Energy-dependent protein degradation is carried out by bipartite assemblies of conserved
architecture. A chaperone ring comprising ATPase domains of the AAA+-type caps both …

Selective proteolysis in plants is largely mediated by the ubiquitin (Ub)/proteasome system
in which substrates, marked by the covalent attachment of Ub, are degraded by the 26 S …