Drugging the efferocytosis process: concepts and opportunities

P Mehrotra, KS Ravichandran - Nature reviews Drug discovery, 2022 - nature.com
The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …

The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer

DK Graham, D DeRyckere, KD Davies… - Nature Reviews Cancer, 2014 - nature.com
The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …

AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

S Wang, Z Qiu, Y Hou, X Deng, W Xu, T Zheng, P Wu… - Cell research, 2021 - nature.com
The current coronavirus disease 2019 (COVID-19) pandemic presents a global public health
challenge. The viral pathogen responsible, severe acute respiratory syndrome coronavirus 2 …

Microglia-mediated synapse loss in Alzheimer's disease

L Rajendran, RC Paolicelli - Journal of Neuroscience, 2018 - Soc Neuroscience
Microglia are emerging as key players in neurodegenerative diseases, such as Alzheimer's
disease (AD). Thus far, microglia have rather been known as modulator of …

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

H Yan, G Zhong, G Xu, W He, Z Jing, Z Gao, Y Huang… - elife, 2012 - elifesciences.org
Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public
health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more …

Virus–receptor interactions: the key to cellular invasion

MS Maginnis - Journal of molecular biology, 2018 - Elsevier
Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …

Biology of the TAM receptors

G Lemke - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …

TAM receptor signaling in immune homeostasis

CV Rothlin, EA Carrera-Silva, L Bosurgi… - Annual review of …, 2015 - annualreviews.org
The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …

Endocytosis of viruses and bacteria

P Cossart, A Helenius - Cold Spring Harbor perspectives …, 2014 - cshperspectives.cshlp.org
Of the many pathogens that infect humans and animals, a large number use cells of the host
organism as protected sites for replication. To reach the relevant intracellular compartments …

The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry

L Meertens, X Carnec, MP Lecoin, R Ramdasi… - Cell host & …, 2012 - cell.com
Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases.
However, the molecular interactions mediating DV entry are poorly understood. We …