Drugging the efferocytosis process: concepts and opportunities
P Mehrotra, KS Ravichandran - Nature reviews Drug discovery, 2022 - nature.com
The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …
The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer
The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells
S Wang, Z Qiu, Y Hou, X Deng, W Xu, T Zheng, P Wu… - Cell research, 2021 - nature.com
The current coronavirus disease 2019 (COVID-19) pandemic presents a global public health
challenge. The viral pathogen responsible, severe acute respiratory syndrome coronavirus 2 …
challenge. The viral pathogen responsible, severe acute respiratory syndrome coronavirus 2 …
Microglia-mediated synapse loss in Alzheimer's disease
L Rajendran, RC Paolicelli - Journal of Neuroscience, 2018 - Soc Neuroscience
Microglia are emerging as key players in neurodegenerative diseases, such as Alzheimer's
disease (AD). Thus far, microglia have rather been known as modulator of …
disease (AD). Thus far, microglia have rather been known as modulator of …
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public
health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more …
health problem. Individuals coinfected with its satellite hepatitis D virus (HDV) have more …
Virus–receptor interactions: the key to cellular invasion
MS Maginnis - Journal of molecular biology, 2018 - Elsevier
Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …
Biology of the TAM receptors
G Lemke - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead …
kinases, in that as a group they play no essential role in embryonic development. Instead …
TAM receptor signaling in immune homeostasis
CV Rothlin, EA Carrera-Silva, L Bosurgi… - Annual review of …, 2015 - annualreviews.org
The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …
Endocytosis of viruses and bacteria
P Cossart, A Helenius - Cold Spring Harbor perspectives …, 2014 - cshperspectives.cshlp.org
Of the many pathogens that infect humans and animals, a large number use cells of the host
organism as protected sites for replication. To reach the relevant intracellular compartments …
organism as protected sites for replication. To reach the relevant intracellular compartments …
The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry
L Meertens, X Carnec, MP Lecoin, R Ramdasi… - Cell host & …, 2012 - cell.com
Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases.
However, the molecular interactions mediating DV entry are poorly understood. We …
However, the molecular interactions mediating DV entry are poorly understood. We …