While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a
large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee …

Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to
Western diet. Three major food classes that promote acne are: 1) hyperglycemic …

Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits
hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent …

The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic
processes. Its properties as an energy sensor allow it to couple the energy status of the cell …

Excessive hepatic glucose production through the gluconeogenesis pathway is partially
responsible for the elevated glucose levels observed in patients with type 2 diabetes …

Current anti-obesity drugs aim to reduce food intake by either curbing appetite or
suppressing the craving for food. However, many of these agents have been associated with …

Vascular endothelial cell (EC) dysfunction strongly induces development of cardiovascular
and cerebrovascular diseases. Epidemiologic studies demonstrated a preventative effect of …

Hepatic glucose production (HGP) plays a vital role in maintaining the supply of glucose to
the body, and transcription factor FoxO1 is known to confer hormone responsiveness onto …

The high sterol concentration in eukaryotic cell membranes is thought to influence
membrane properties such as permeability, fluidity and microdomain formation. Drosophila …