[HTML][HTML] The quest for multiscale brain modeling

E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …

Questions and controversies in the study of time-varying functional connectivity in resting fMRI

DJ Lurie, D Kessler, DS Bassett, RF Betzel… - Network …, 2020 - direct.mit.edu
The brain is a complex, multiscale dynamical system composed of many interacting regions.
Knowledge of the spatiotemporal organization of these interactions is critical for establishing …

[HTML][HTML] Geometric constraints on human brain function

JC Pang, KM Aquino, M Oldehinkel, PA Robinson… - Nature, 2023 - nature.com
The anatomy of the brain necessarily constrains its function, but precisely how remains
unclear. The classical and dominant paradigm in neuroscience is that neuronal dynamics …

Methodological considerations for studying neural oscillations

T Donoghue, N Schaworonkow… - European journal of …, 2022 - Wiley Online Library
Neural oscillations are ubiquitous across recording methodologies and species, broadly
associated with cognitive tasks, and amenable to computational modelling that investigates …

A cross-disorder connectome landscape of brain dysconnectivity

MP van den Heuvel, O Sporns - Nature reviews neuroscience, 2019 - nature.com
Many human brain disorders are associated with characteristic alterations in the structural
and functional connectivity of the brain. In this article, we explore how commonalities and …

Heritability and interindividual variability of regional structure-function coupling

Z Gu, KW Jamison, MR Sabuncu… - Nature Communications, 2021 - nature.com
White matter structural connections are likely to support flow of functional activation or
functional connectivity. While the relationship between structural and functional connectivity …

[HTML][HTML] Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

F Maestú, W de Haan, MA Busche, J DeFelipe - Ageing Research Reviews, 2021 - Elsevier
Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core

G Deco, ML Kringelbach, VK Jirsa, P Ritter - Scientific reports, 2017 - nature.com
In the human brain, spontaneous activity during resting state consists of rapid transitions
between functional network states over time but the underlying mechanisms are not …

[HTML][HTML] The virtual epileptic patient: individualized whole-brain models of epilepsy spread

VK Jirsa, T Proix, D Perdikis, MM Woodman, H Wang… - Neuroimage, 2017 - Elsevier
Individual variability has clear effects upon the outcome of therapies and treatment
approaches. The customization of healthcare options to the individual patient should …

Activity flow over resting-state networks shapes cognitive task activations

MW Cole, T Ito, DS Bassett, DH Schultz - Nature neuroscience, 2016 - nature.com
Resting-state functional connectivity (FC) has helped reveal the intrinsic network
organization of the human brain, yet its relevance to cognitive task activations has been …