Bacteria must rapidly respond to both intracellular and environmental changes to survive.
One critical mechanism to rapidly detect and adapt to changes in environmental conditions …

Understanding the genetic design principles that determine protein production remains a
major challenge. Although the key principles of gene expression were discovered 50 years …

Shine-Dalgarno (SD) motifs are thought to play an important role in translational initiation in
bacteria. Paradoxically, ribosome profiling studies in E. coli show no correlation between the …

Translation efficiency has been mainly studied by ribosome profiling, which only provides an
incomplete picture of translation kinetics. Here, we integrated the absolute quantifications of …

Bacteria of the genus Bacteroides are common members of the human intestinal microbiota
and important degraders of polysaccharides in the gut. Among them, the species …

ABSTRACT Shine-Dalgarno (SD) sequences, the core element of prokaryotic ribosome-
binding sites, facilitate mRNA translation by base-pair interaction with the anti-SD (aSD) …

Most bacterial ORFs are identified by automated prediction algorithms. However, these
algorithms often fail to identify ORFs lacking canonical features such as a length of> 50 …

Genomic studies have indicated that certain bacterial lineages such as the Bacteroidetes
lack Shine-Dalgarno (SD) sequences, and yet with few exceptions ribosomes of these …

Abstract Ribosomes of Bacteroidia (formerly Bacteroidetes) fail to recognize Shine-Dalgarno
(SD) sequences even though they harbor the anti-SD (ASD) of 16S rRNA. Inhibition of SD …

Paramount to human health, symbiotic bacteria in the gastrointestinal tract rely on the
breakdown of complex polysaccharides to thrive in this sugar-deprived environment. Gut …