Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well.
Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which …

Cell migration and invasion is a key driving factor for providing essential cellular functions
under physiological conditions or the malignant progression of tumors following downward …

Aim: To develop novel siRNA delivery system overcoming the limitations of synthetic
nanoparticles, such as potential side effects, nonspecificity and economic production for …

Nanotechnology has enabled the delivery of small molecular drugs packaged in nanosized
vesicles to the target tissues. Plant-Derived Nanoparticles (PDNPs) are vesicles with natural …

Integrins are an important family of adhesion molecules that were first discovered two
decades ago. Integrins are transmembrane heterodimeric glycoprotein receptors consisting …

Purpose We explored differences in survival between primary tumor locations, hereby
focusing on the role of metastatic sites in synchronous metastatic colorectal cancer (mCRC) …

Colorectal cancer is the second most common cancer diagnosed in men and the third most
commonly occurring in women worldwide. Interactions between cells and the surrounding …

The β1-integrin receptor is broadly expressed on tumor and other cells in the tumor
microenvironment (TME), and is an unfavorable prognostic factor for cancers. Nature …

Colorectal cancer (CRC) is the third most common cancer in the world and distant
metastasis is the leading cause of death among CRC patients. However, the underlying …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor. Acinar-
to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN) are both …