Role for the propofol hydroxyl in anesthetic protein target molecular recognition
KA Woll, BP Weiser, Q Liang, T Meng… - ACS chemical …, 2015 - ACS Publications
Propofol is a widely used intravenous general anesthetic. We synthesized 2-fluoro-1, 3-
diisopropylbenzene, a compound that we call “fropofol”, to directly assess the significance of …
diisopropylbenzene, a compound that we call “fropofol”, to directly assess the significance of …
Discovery of a novel general anesthetic chemotype using high-throughput screening
AR McKinstry-Wu, W Bu, G Rai, WA Lea… - …, 2015 - pubs.asahq.org
Background: The development of novel anesthetics has historically been a process of
combined serendipity and empiricism, with most recent new anesthetics developed via …
combined serendipity and empiricism, with most recent new anesthetics developed via …
[HTML][HTML] Antagonism of Propofol Anesthesia by Alkyl-fluorobenzene Derivatives
DM Plasencia, LH Rodgers, AR Knighton… - Research …, 2024 - ncbi.nlm.nih.gov
Despite their frequent use across many clinical settings, general anesthetics are
medications with lethal side effects and no reversal agents. A fluorinated analogue of …
medications with lethal side effects and no reversal agents. A fluorinated analogue of …
[PDF][PDF] Antagonism of Propofol Anesthesia by Alkyl-uorobenzene Derivatives
DM Plasencia, LH Rodgers, AR Knighton… - assets-eu.researchsquare.com
Despite their frequent use across many clinical settings, general anesthetics are
medications with lethal side effects and no reversal agents. A fluorinated analogue of …
medications with lethal side effects and no reversal agents. A fluorinated analogue of …