Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the
treatment of a wide variety of cancers. Several such compounds, including gemcitabine and …

The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history
with over 28,000 cases, resulting in> 11,000 deaths including> 500 healthcare workers. A …

A series of 1′-substituted analogs of 4-aza-7, 9-dideazaadenosine C-nucleoside were
prepared and evaluated for the potential as antiviral agents. These compounds showed a …

US9090642B2 - Methods for the preparation of diasteromerically pure phosphoramidate
prodrugs - Google Patents US9090642B2 - Methods for the preparation of diasteromerically pure …

Novel 2 '-deoxycytidine antimetabolites, specifically several 2 '-modified 2 '-deoxy-4 '-
thiocytidines, were synthesized as potential new antineoplastic agents. Methyl 3-O …

US8008264B2 - 1′-substituted carba-nucleoside analogs for antiviral treatment - Google
Patents US8008264B2 - 1′-substituted carba-nucleoside analogs for antiviral treatment …

(57) ABSTRACT Provided are pyrrolo 1.2-f 1.2. 4 triazinyl, imidazo 1.5-f1. 2.4 triazinyl,
imidazo 1.2-f 1.2. 4 triazinyl, and 1.2. 4 tria Zolo 4.3-f1. 2.4 triazinyl nucleosides, nucleoside …

2016-10-13 Assigned to GILEAD SCIENCES, INC. reassignment GILEAD SCIENCES, INC.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

4,816,570 A 3/1989 Farquhar 4,968,788 A 1 1/1990 Farquhar 5,663,159 A 9/1997 Starrett,
Jr. et al. 5,792,756 A 8/1998 Starrett, Jr. et al. 6,312,662 B1 1 1/2001 Erion et al. 6,476,030 …

US10023600B2 - Processes and intermediates for the preparation of 1′-substituted carba-nucleoside
analogs - Google Patents US10023600B2 - Processes and intermediates for the preparation …