Cholesterol and Alzheimer's disease; from risk genes to pathological effects
FM Feringa, R Van der Kant - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
While the central nervous system compromises 2% of our body weight, it harbors up to 25%
of the body's cholesterol. Cholesterol levels in the brain are tightly regulated for …
of the body's cholesterol. Cholesterol levels in the brain are tightly regulated for …
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …
conditions and increased prevalence is of public concern. Recent research has provided …
Comprehensive evaluation of the 5XFAD mouse model for preclinical testing applications: a MODEL-AD study
The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model (s) being used. There are …
diseases depends on extensive characterization of the model (s) being used. There are …
Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease
RE Bennett, AB Robbins, M Hu, X Cao… - Proceedings of the …, 2018 - National Acad Sciences
Mixed pathology, with both Alzheimer's disease and vascular abnormalities, is the most
common cause of clinical dementia in the elderly. While usually thought to be concurrent …
common cause of clinical dementia in the elderly. While usually thought to be concurrent …
Resveratrol: French paradox revisited
B Catalgol, S Batirel, Y Taga, NK Ozer - Frontiers in pharmacology, 2012 - frontiersin.org
Resveratrol is a polyphenol that plays a potentially important role in many disorders and has
been studied in different diseases. The research on this chemical started through the …
been studied in different diseases. The research on this chemical started through the …
The role of type 2 diabetes in neurodegeneration
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …
Is Alzheimer's disease risk modifiable?
A Serrano-Pozo, JH Growdon - Journal of Alzheimer's disease, 2019 - content.iospress.com
Population-based clinic-pathological studies have established that the most common
pathological substrate of dementia in community-dwelling elderly people is mixed …
pathological substrate of dementia in community-dwelling elderly people is mixed …
Current understanding of the physiopathology, diagnosis and therapeutic approach to Alzheimer's disease
V García-Morales, A González-Acedo… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia. It is characterized by
cognitive decline and progressive memory loss. The aim of this review was to update the …
cognitive decline and progressive memory loss. The aim of this review was to update the …
Mechanistic link between vitamin B12 and Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly population,
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …
Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin
Amyloid beta peptide (Aβ) has a key role in the pathological process of Alzheimer's disease
(AD), but the physiological function of Aβ and of the amyloid precursor protein (APP) is …
(AD), but the physiological function of Aβ and of the amyloid precursor protein (APP) is …