[HTML][HTML] JAK-STAT signaling: a double-edged sword of immune regulation and cancer progression

KL Owen, NK Brockwell, BS Parker - Cancers, 2019 - mdpi.com
Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates
almost all immune regulatory processes, including those that are involved in tumor cell …

[HTML][HTML] An aberrant STAT pathway is central to COVID-19

T Matsuyama, SP Kubli, SK Yoshinaga… - Cell Death & …, 2020 - nature.com
COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical
symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS …

[HTML][HTML] Repurposing drugs, ongoing vaccine, and new therapeutic development initiatives against COVID-19

RP Saha, AR Sharma, MK Singh, S Samanta… - Frontiers in …, 2020 - frontiersin.org
As the COVID-19 is still growing throughout the globe, a thorough investigation into the
specific immunopathology of SARS-CoV-2, its interaction with the host immune system and …

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states

K Leng, IVL Rose, H Kim, W Xia… - Nature …, 2022 - nature.com
Astrocytes become reactive in response to insults to the central nervous system by adopting
context-specific cellular signatures and outputs, but a systematic understanding of the …

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across

AK Minnaert, H Vanluchene, R Verbeke… - Advanced drug delivery …, 2021 - Elsevier
The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-
2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA …

circFAT1 promotes cancer stemness and immune evasion by promoting STAT3 activation

L Jia, Y Wang, CY Wang - Advanced Science, 2021 - Wiley Online Library
Cancer stemness and immune evasion are closely associated, and play critical roles in
tumor development and resistance to immunotherapy. However, little is known about the …

Contribution of STAT3 to the pathogenesis of COVID-19

A Jafarzadeh, M Nemati, S Jafarzadeh - Microbial pathogenesis, 2021 - Elsevier
Hyper-inflammatory responses, lymphopenia, unbalanced immune responses, cytokine
storm, large viral replication and massive cell death play fundamental roles in the …

[HTML][HTML] The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes

PK West, AN McCorkindale, B Guennewig… - Journal of …, 2022 - Springer
Background Elevated production of the cytokines interleukin (IL)-6 or interferon (IFN)-α in the
central nervous system (CNS) is implicated in the pathogenesis of neurological diseases …

[HTML][HTML] Traumatic brain injury induces cGAS activation and type I interferon signaling in aged mice

JP Barrett, SM Knoblach, S Bhattacharya… - Frontiers in …, 2021 - frontiersin.org
Aging adversely affects inflammatory processes in the brain, which has important
implications in the progression of neurodegenerative disease. Following traumatic brain …

Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo

X Ding, AC Sharko, MSJ McDermott… - Proceedings of the …, 2022 - National Acad Sciences
Breast cancers (BrCas) that overexpress oncogenic tyrosine kinase receptor HER2 are
treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase …