Chondrosarcoma is a primary malignant bone tumor. Traditional therapy is not very effective,
and it is prone to metastasis in the late stage. The tumor microenvironment (TME) plays a …

Osteoarthritis (OA) is a prevalent joint disease commonly associated with aging and obesity,
which can lead to pain, stiffness, joint dysfunction, and disability. Omentin-1 (also called …

Macrophages are innate immune cells that play key roles during both homeostasis and
disease. Depending on the microenvironmental cues sensed in different tissues …

Flavonoids exhibit health-promoting benefits against multiple chronic diseases, including
cancer. Apigenin (4′, 5, 7-trihydroxyflavone), one flavonoid present in fruits and …

Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous
tissue and is associated with lung metastases. Extracellular vesicles called exosomes are …

Metabolic reprogramming is recognized as a hallmark of cancer, enabling cancer cells to
acquire essential biomolecules for cell growth, often characterized by upregulated glycolysis …

New therapeutic approaches are needed for metastatic osteosarcoma (OS), as survival rates
remain low despite surgery and chemotherapy. Epigenetic changes, such as histone H3 …

Osteoarthritis (OA) is a low-grade inflammatory joint illness in which monocytes migrate and
infiltrate synovial tissue, differentiating into the pro-inflammatory M1 macrophage phenotype …

Background Fatty acid synthase (FASN), a key rate-limiting enzyme in the fatty acid
biosynthesis pathway has been identified to be overexpressed in breast cancer. This …

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder in which
monocytes adhering to synovial tissue differentiate into the pro-inflammatory M1 …