The pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, and Leishmania
spp. are the causative agents of African trypanosomiasis, Chagas disease, and …

Leishmania and Trypanosoma belong to the Trypanosomatidae family and cause important
human infections such as leishmaniasis, Chagas disease, and sleeping sickness …

Trypanosoma cruzi, the causative agent of Chagas disease, is an obligatory intracellular
parasite with a digenetic life cycle. Due to the variety of host environments, it faces several …

Extracellular vesicles (EVs) are small lipid vesicles released by either any prokaryotic or
eukaryotic cell, or both, with a biological role in cell-to-cell communication. In this work, we …

Chagas disease is caused by the hemoflagellate protozoa Trypanosoma cruzi and is one of
the most important neglected tropical diseases, especially in Latin American countries …

The toxicity of oxygen and nitrogen reactive species appears to be merely the tip of the
iceberg in the world of redox homeostasis. Now, oxidative stress can be seen as a two-sided …

Body tissues are subjected to various oxygenic gradients and fluctuations and hence can
become transiently hypoxic. Hypoxia-inducible factor (HIF) is the master transcriptional …

Chagas disease is a neglected disease, caused by the protozoan Trypanosoma cruzi. This
kinetoplastid presents a cycle involving different forms and hosts, being trypomastigotes the …

Mitochondrial F-type adenosine triphosphate (ATP) synthases are commonly introduced as
highly conserved membrane-embedded rotary machines generating the majority of cellular …

Chagas disease is a neglected illness endemic in Latin America that mainly affects rural
populations. The etiological agent of Chagas disease is the protozoan Trypanosoma cruzi …