Tumor-treating fields: a fourth modality in cancer treatment

EJ Mun, HM Babiker, U Weinberg, ED Kirson… - Clinical Cancer …, 2018 - AACR
Despite major advances in therapy, cancer continues to be a leading cause of mortality. In
addition, toxicities of traditional therapies pose a significant challenge to tolerability and …

[PDF][PDF] The mechanisms of action of Tumor Treating Fields

JC Moser, E Salvador, K Deniz, K Swanson… - Cancer research, 2022 - AACR
Abstract Tumor Treating Fields (TTFields), a new modality of cancer treatment, are electric
fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment …

[HTML][HTML] Mitotic spindle disruption by alternating electric fields leads to improper chromosome segregation and mitotic catastrophe in cancer cells

M Giladi, RS Schneiderman, T Voloshin, Y Porat… - Scientific reports, 2015 - nature.com
Abstract Tumor Treating Fields (TTFields) are low intensity, intermediate frequency,
alternating electric fields. TTFields are a unique anti-mitotic treatment modality delivered in a …

[HTML][HTML] Increased compliance with tumor treating fields therapy is prognostic for improved survival in the treatment of glioblastoma: a subgroup analysis of the EF-14 …

SA Toms, CY Kim, G Nicholas, Z Ram - Journal of neuro-oncology, 2019 - Springer
Abstract Background Tumor treating fields (TTFields) is a non-invasive, antimitotic therapy.
In the EF-14 phase 3 trial in newly diagnosed glioblastoma, TTFields plus temozolomide …

Tumor treating fields: a novel treatment modality and its use in brain tumors

AF Hottinger, P Pacheco, R Stupp - Neuro-oncology, 2016 - academic.oup.com
Tumor treating fields (TTFields) are low-intensity electric fields alternating at an intermediate
frequency (200kHz), which have been demonstrated to block cell division and interfere with …

Tumor Treating Fields therapy with standard systemic therapy versus standard systemic therapy alone in metastatic non-small-cell lung cancer following progression …

T Leal, R Kotecha, R Ramlau, L Zhang… - The Lancet …, 2023 - thelancet.com
Summary Background Tumor Treating Fields (TTFields) are electric fields that disrupt
processes critical for cancer cell survival, leading to immunogenic cell death and enhanced …

[HTML][HTML] Tumor treating fields increases membrane permeability in glioblastoma cells

E Chang, CB Patel, C Pohling, C Young, J Song… - Cell death …, 2018 - nature.com
Glioblastoma is the most common yet most lethal of primary brain cancers with a one-year
post-diagnosis survival rate of 65% and a five-year survival rate of barely 5%. Recently the …

[HTML][HTML] Tumor-treating fields in glioblastomas: past, present, and future

X Guo, X Yang, J Wu, H Yang, Y Li, J Li, Q Liu, C Wu… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma (GBM) is the most common malignant primary brain tumor.
Although the standard of care, including maximal resection, concurrent radiotherapy with …

An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields

Y Yang, X Hu, Y Liu, B Ouyang, J Zhang, H Jin, Z Yu… - Science …, 2022 - science.org
Brain tumors have been proved challenging to treat. Here, we present a promising
alternative by developing an implantable ultrasound-powered tumor treating device (UP …

[HTML][HTML] Tumor treating fields (TTFields) delay DNA damage repair following radiation treatment of glioma cells

M Giladi, M Munster, RS Schneiderman, T Voloshin… - Radiation …, 2017 - Springer
Abstract Background Tumor Treating Fields (TTFields) are an anti-neoplastic treatment
modality delivered via application of alternating electric fields using insulated transducer …