Mycobacterium tuberculosis infection of host cells in space and time
C Bussi, MG Gutierrez - FEMS microbiology reviews, 2019 - academic.oup.com
Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …
The granuloma in tuberculosis: dynamics of a host–pathogen collusion
S Ehlers, UE Schaible - Frontiers in immunology, 2013 - frontiersin.org
A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …
limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the …
Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in …
Abstract Development of an effective tuberculosis (TB) vaccine has suffered from an
incomplete understanding of the correlates of protection against Mycobacterium tuberculosis …
incomplete understanding of the correlates of protection against Mycobacterium tuberculosis …
Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate
MP Hall, J Unch, BF Binkowski, MP Valley… - ACS chemical …, 2012 - ACS Publications
Bioluminescence methodologies have been extraordinarily useful due to their high
sensitivity, broad dynamic range, and operational simplicity. These capabilities have been …
sensitivity, broad dynamic range, and operational simplicity. These capabilities have been …
Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis
Infections caused by antibiotic-resistant bacteria are a rising public health threat and make
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …
the identification of new antibiotics a priority. From a cell-based screen for bactericidal …
Design of a broad-range bacteriophage cocktail that reduces Pseudomonas aeruginosa biofilms and treats acute infections in two animal models
The alarming diffusion of multidrug-resistant (MDR) bacterial strains requires investigations
on nonantibiotic therapies. Among such therapies, the use of bacteriophages (phages) as …
on nonantibiotic therapies. Among such therapies, the use of bacteriophages (phages) as …
Seeing (and using) the light: recent developments in bioluminescence technology
AC Love, JA Prescher - Cell Chemical Biology, 2020 - cell.com
Bioluminescence has long been used to image biological processes in vivo. This technology
features luciferase enzymes and luciferin small molecules that produce visible light …
features luciferase enzymes and luciferin small molecules that produce visible light …
Zebrafish embryos and larvae: a new generation of disease models and drug screens
Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …
Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape
C Baranowski, MA Welsh, LT Sham, HA Eskandarian… - Elife, 2018 - elifesciences.org
In most well-studied rod-shaped bacteria, peptidoglycan is primarily crosslinked by penicillin-
binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L, D …
binding proteins (PBPs). However, in mycobacteria, crosslinks formed by L, D …
NAD (H) homeostasis underlies host protection mediated by glycolytic myeloid cells in tuberculosis
Mycobacterium tuberculosis (Mtb) disrupts glycolytic flux in infected myeloid cells through an
unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably …
unclear mechanism. Flux through the glycolytic pathway in myeloid cells is inextricably …