ERK signalling: a master regulator of cell behaviour, life and fate
H Lavoie, J Gagnon, M Therrien - Nature reviews Molecular cell biology, 2020 - nature.com
The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …
[HTML][HTML] The human transcription factors
Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …
transcription, forming a complex system that guides expression of the genome. Despite keen …
[HTML][HTML] Sequence-dependent surface condensation of a pioneer transcription factor on DNA
Biomolecular condensates are dense assemblies of proteins that form distinct biochemical
compartments without being surrounded by a membrane. Some, such as P granules and …
compartments without being surrounded by a membrane. Some, such as P granules and …
[HTML][HTML] SOD1, more than just an antioxidant
ECA Eleutherio, RSS Magalhães… - Archives of Biochemistry …, 2021 - Elsevier
During cellular respiration, radicals, such as superoxide, are produced, and in a large
concentration, they may cause cell damage. To combat this threat, the cell employs the …
concentration, they may cause cell damage. To combat this threat, the cell employs the …
Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …
[HTML][HTML] The genetics of transcription factor DNA binding variation
Most complex trait-associated variants are located in non-coding regulatory regions of the
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …
A nuclease that mediates cell death induced by DNA damage and poly (ADP-ribose) polymerase-1
Y Wang, R An, GK Umanah, H Park, K Nambiar… - Science, 2016 - science.org
INTRODUCTION Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) is a nuclear enzyme
responding to oxidative stress and DNA damage. Excessive activation of PARP-1 causes an …
responding to oxidative stress and DNA damage. Excessive activation of PARP-1 causes an …
[HTML][HTML] Regulation of chromatin by histone modifications
AJ Bannister, T Kouzarides - Cell research, 2011 - nature.com
Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to
external cues to regulate the many uses of DNA. A principle component of chromatin that …
external cues to regulate the many uses of DNA. A principle component of chromatin that …
Highly sensitive and multiplexed protein measurements
Proteins are involved in many biological processes. Misfolded, truncated, or mutated
proteins as well as over-or underexpressed proteins have been implicated in many …
proteins as well as over-or underexpressed proteins have been implicated in many …
[HTML][HTML] The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation
The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …