[HTML][HTML] Advances and challenges in the treatment of lung cancer

Y Li, B Yan, S He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Lung cancer accounts for a relatively high proportion of malignant tumors. As the most
prevalent type of lung cancer, non-small cell lung cancer (NSCLC) is characterized by high …

Using ncRNAs as tools in Cancer diagnosis and treatment—the way towards personalized medicine to improve patients' health

R Piergentili, G Basile, C Nocella, R Carnevale… - International journal of …, 2022 - mdpi.com
Although the first discovery of a non-coding RNA (ncRNA) dates back to 1958, only in recent
years has the complexity of the transcriptome started to be elucidated. However, its …

lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling

X Lin, S Zhuang, X Chen, J Du, L Zhong, J Ding… - Molecular Therapy, 2022 - cell.com
Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and progression of
colorectal cancer (CRC). However, functions of most lncRNAs in CRC and their molecular …

m6A modification of lncRNA PCAT6 promotes bone metastasis in prostate cancer through IGF2BP2‐mediated IGF1R mRNA stabilization

C Lang, C Yin, K Lin, Y Li, Q Yang, Z Wu… - Clinical and …, 2021 - Wiley Online Library
Background Bone metastasis is the leading cause of tumor‐related death in prostate cancer
(PCa) patients. Long noncoding RNAs (lncRNAs) have been well documented to be …

Ferroptosis in non-small cell lung cancer: progression and therapeutic potential on it

J Zou, L Wang, H Tang, X Liu, F Peng… - International Journal of …, 2021 - mdpi.com
As a main subtype of lung cancer, the current situation of non-small cell lung cancer
(NSCLC) remains severe worldwide with a 19% survival rate at 5 years. As the conventional …

RNA-based therapies: A cog in the wheel of lung cancer defense

P Khan, JA Siddiqui, I Lakshmanan, AK Ganti, R Salgia… - Molecular cancer, 2021 - Springer
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …

Overexpression of the SARS‐CoV‐2 receptor ACE2 is induced by cigarette smoke in bronchial and alveolar epithelia

A Liu, X Zhang, R Li, M Zheng, S Yang… - The Journal of …, 2021 - Wiley Online Library
Abstract Angiotensin‐converting enzyme 2 (ACE2) has been identified as the functional
receptor of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and a target for …

The crosstalk between reactive oxygen species and noncoding RNAs: From cancer code to drug role

J Zuo, Z Zhang, M Li, Y Yang, B Zheng, P Wang… - Molecular Cancer, 2022 - Springer
Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen
species (ROS), is an emerging hallmark of cancer. Tumorigenesis and development driven …

SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway

X Liu, S Shen, L Zhu, R Su, J Zheng, X Ruan… - Journal of Experimental …, 2020 - Springer
Background Angiogenesis plays an important role in the progress of glioma. RNA-binding
proteins (RBPs) and circular RNAs (circRNAs), dysregulated in various tumors, have been …

Breast cancer derived exosomes promoted angiogenesis of endothelial cells in microenvironment via circHIPK3/miR-124-3p/MTDH axis

P Shi, Y Liu, H Yang, B Hu - Cellular signalling, 2022 - Elsevier
Circular RNAs (circRNAs) are important contents in exosomes, which can regulate
peripheral cell functions, thus influencing the tumor microenvironment. This work …