Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Complex carbohydrates are ubiquitous in nature, and together with proteins and nucleic
acids they comprise the building blocks of life. But unlike proteins and nucleic acids …

While the HIV-1-glycan shield is known to shelter Env from the humoral immune response,
its quantitative impact on antibody elicitation has been unclear. Here, we use targeted …

Fast photochemical oxidation of proteins (FPOP) is a MS-based method that has proved
useful in studies of protein structures, interactions, conformations, and protein folding. The …

Protein footprinting coupled with mass spectrometry is being increasingly used for the study
of protein interactions and conformations. The hydroxyl radical footprinting method, fast …

Recently, mass spectrometry (MS) has become a viable method for elucidation of protein
structure. Surface-induced dissociation (SID), colliding multiply charged protein complexes …

Biotherapeutics and their biosimilar versions have been flourishing in the biopharmaceutical
market for several years. Structural and functional characterization is needed to achieve …

Heterologous protein production is widely used in industrial biotechnology. However, using
non-native production hosts can lead to enzymes with altered post-translational …

Commercial monoclonal antibodies are growing and important components of modern
therapies against a multitude of human diseases. Well-known high-resolution structural …

Highlights•Viral protein simulations are among the largest all-atom simulations ever
published.•All-atom simulations reveal the dynamics of viral proteins at chemical …