Available evidence indicates that qualitative changes in hematopoietic stem cells and
progenitors, such as the decision of stem cells to self-renew or differentiate, or selection of …

EMATOPOIESIS IS A quantitatively imposing pro-H cess in the adult, where about 3 x lo9
erythroid cells/kg and lo9 myeloid celis/kg are generated each day. Twenty-five years ago, in …

Experiments were conducted to isolate and characterize the gene and gene product of a
human hematopoietic colony-stimulating factor with pluripotent biological activities. This …

The complementary DNAs and genes encoding the four major human myeloid growth
factors—granulocyte colony-stimulating factor, macrophage colony-stimulating factor …

There is increasing evidence that epidermal cytokines may have an important role in
mediating inflammatory and immune responses in the skin. A number of cell types in the …

A cDNA clone encoding a novel hematopoietic growth factor activity produced by a gibbon T
cell line has been identified using a mammalian cell expression cloning system. The …

Eight permanent cell lines were established from cells of 50 consecutive patients with
childhood acute leukemia. Three cell lines required growth factor-containing conditioned …

The nervous system, through the production of neuroregulators (neurotransmitters,
neuromodulators and neuropeptides) can regulate specific immune system functions, while …

The process of blood cell formation, by which a small number of self-renewing stem cells
give rise to lineage committed pro-genitor cells that subsequently proliferateand differentiate …

Cultured mononuclear phagocytes produce soluble factors that stimulate endothelial cells to
release GM-colony-stimulating activity (GM-CSA). One such factor was recently identified as …