[HTML][HTML] AhR signaling pathways and regulatory functions
L Larigot, L Juricek, J Dairou, X Coumoul - Biochimie open, 2018 - Elsevier
Animals and humans are exposed each day to a multitude of chemicals in the air, water and
food. They have developed a battery of enzymes and transporters that facilitate the …
food. They have developed a battery of enzymes and transporters that facilitate the …
Human cytochromes P450 in health and disease
There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …
Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy
T Efferth, E Koch - Current drug targets, 2011 - ingentaconnect.com
Drugs derived from natural resources represent a significant segment of the pharmaceutical
market as compared to randomly synthesized compounds. It is a goal of drug development …
market as compared to randomly synthesized compounds. It is a goal of drug development …
Clinical importance of the cytochromes P450
DW Nebert, DW Russell - The Lancet, 2002 - thelancet.com
The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for
enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid …
enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid …
Insect P450 enzymes
R Feyereisen - Annual review of entomology, 1999 - annualreviews.org
▪ Abstract The P450 enzymes (mixed function oxidases, cytochrome P450
monooxygenases), a diverse class of enzymes found in virtually all insect tissues, fulfill …
monooxygenases), a diverse class of enzymes found in virtually all insect tissues, fulfill …
Induction of phase I, II and III drug metabolism/transport by xenobiotics
C Xu, CYT Li, ANT Kong - Archives of pharmacal research, 2005 - Springer
Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and
detoxification of xenobiotics and drugs introduced into the human body. Most of the tissues …
detoxification of xenobiotics and drugs introduced into the human body. Most of the tissues …
Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences.
O Gotoh - Journal of Biological Chemistry, 1992 - ASBMB
The substrate recognition regions in cytochrome P450 family 2 (CYP2) proteins were
inferred by group-to-group alignment of CYP2 sequences and those of bacterial P450s …
inferred by group-to-group alignment of CYP2 sequences and those of bacterial P450s …
The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans
PB Danielson - Current drug metabolism, 2002 - ingentaconnect.com
Cytochrome P450s comprise a superfamily of heme-thiolate proteins named for the spectral
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in …
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
P Fernandez-Salguero, T Pineau, DM Hilbert… - Science, 1995 - science.org
The aryl hydrocarbon (Ah) receptor (AHR) mediates many carcinogenic and teratogenic
effects of environmentally toxic chemicals such as dioxin. An AHR-deficient (Ahr-/-) mouse …
effects of environmentally toxic chemicals such as dioxin. An AHR-deficient (Ahr-/-) mouse …
Role of pharmacokinetics and metabolism in drug discovery and development
JH Lin, AYH Lu - Pharmacological reviews, 1997 - ASPET
Drug research encompasses several diverse disciplines united by a common goal, namely
the development of novel therapeutic agents. The search for new drugs can be divided …
the development of novel therapeutic agents. The search for new drugs can be divided …